Document Detail

Lysis of erythrocytes by phosphatidylcholine containing polyunsaturated fatty acid.
MedLine Citation:
PMID:  6874658     Owner:  NLM     Status:  MEDLINE    
Egg yolk phosphatidylcholine liposomes induced lysis of erythrocytes from various animals. Hemolysis of human erythrocytes occurred only above 37 degrees C. The incorporation of cholesterol and dicetylphosphate into liposomes did not affect the hemolytic activity of the phosphatidylcholine liposomes. Hemolysis was inhibited by EDTA and serum albumin. Liposomes prepared from rat liver phosphatidylcholine or those from synthetic dilinoleoylglycerophosphocholine are also hemolytic to human erythrocytes, whereas dimyristoyl- and dioleoylglycerophosphocholines are not. These findings indicate that the polyunsaturated fatty acid residues might be very important for the hemolytic activity of these phosphatidylcholine liposomes.
T Kobayashi; K Takahashi; A Yamada; S Nojima; K Inoue
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biochemistry     Volume:  93     ISSN:  0021-924X     ISO Abbreviation:  J. Biochem.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-09-09     Completed Date:  1983-09-09     Revised Date:  2007-12-19    
Medline Journal Info:
Nlm Unique ID:  0376600     Medline TA:  J Biochem     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  675-80     Citation Subset:  IM    
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MeSH Terms
Egg Yolk
Erythrocyte Membrane / drug effects
Fatty Acids, Unsaturated / pharmacology*
Hemolysis / drug effects*
Liposomes / pharmacology
Phosphatidylcholines / pharmacology*
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Liposomes; 0/Phosphatidylcholines

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