| Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia. | |
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MedLine Citation:
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PMID: 21674790 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Phytochemical studies on the branches and leaves of Lyonia ovalifolia yielded a new grayanane diterpenoid, lyonin A (1), together with two known compounds, secorhodomollolides A and D (2 and 3, resp.). The structure of 1 was elucidated by combination of 1D- and 2D-NMR, and MS analyses. Compound 1 turned out to be a new, highly O-acylated grayanane diterpenoid, of which ring B has undergone an oxidative cleavage between C(9) and C(10), yielding a system differing from the previously reported grayanane type with a 5/7/6/5 ring system. Results of the cAMP regulation activity assay showed that compounds 2 and 3 at 50 μM induced a significantly decreased cAMP level in N1E-115 neuroblastoma cells (p<0.001), indicating neuropharmacological potential. |
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Authors:
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Zhao-Yuan Wu; Hai-Zhou Li; Wei-Guang Wang; Hong-Mei Li; Rui Chen; Rong-Tao Li; Huai-Rong Luo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemistry & biodiversity Volume: 8 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1182-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich. |
Affiliation:
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The College of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650224, P. R. China (phone: +86-871-3856880; fax: +86-871-3801956); The College of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, P. R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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