Document Detail

Lynch syndrome in colorectal cancer patients.
MedLine Citation:
PMID:  18402524     Owner:  NLM     Status:  MEDLINE    
Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is the most common form of hereditary colorectal cancer. It is characterized by early onset of colorectal cancer and other extracolonic-associated malignancies. This disorder is inherited in an autosomal dominant pattern and is due to a mutation in one of the DNA mismatch repair genes. Although clinical and molecular understanding of the syndrome has progressed dramatically in the last decade, diagnosis of the syndrome is still a clinical challenge. This review summarizes the main features of the syndrome and provides an update of its management.
M Dolores Giráldez; Sergi Castellví-Bel; Francesc Balaguer; Victòria Gonzalo; Teresa Ocaña; Antoni Castells
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of anticancer therapy     Volume:  8     ISSN:  1744-8328     ISO Abbreviation:  Expert Rev Anticancer Ther     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-11     Completed Date:  2008-05-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101123358     Medline TA:  Expert Rev Anticancer Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  573-83     Citation Subset:  IM    
Department of Gastroenterology, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain.
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MeSH Terms
Colorectal Neoplasms, Hereditary Nonpolyposis* / diagnosis,  genetics,  therapy
DNA Mismatch Repair*
Genetic Predisposition to Disease*
Microsatellite Instability

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