Document Detail


Lynch syndrome in colorectal cancer patients.
MedLine Citation:
PMID:  18402524     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is the most common form of hereditary colorectal cancer. It is characterized by early onset of colorectal cancer and other extracolonic-associated malignancies. This disorder is inherited in an autosomal dominant pattern and is due to a mutation in one of the DNA mismatch repair genes. Although clinical and molecular understanding of the syndrome has progressed dramatically in the last decade, diagnosis of the syndrome is still a clinical challenge. This review summarizes the main features of the syndrome and provides an update of its management.
Authors:
M Dolores Giráldez; Sergi Castellví-Bel; Francesc Balaguer; Victòria Gonzalo; Teresa Ocaña; Antoni Castells
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of anticancer therapy     Volume:  8     ISSN:  1744-8328     ISO Abbreviation:  Expert Rev Anticancer Ther     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-11     Completed Date:  2008-05-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101123358     Medline TA:  Expert Rev Anticancer Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  573-83     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. mgiralde@clinic.ub.es
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MeSH Terms
Descriptor/Qualifier:
Colorectal Neoplasms, Hereditary Nonpolyposis* / diagnosis,  genetics,  therapy
DNA Mismatch Repair*
Genetic Predisposition to Disease*
Humans
Immunohistochemistry
Microsatellite Instability
Mutation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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