| Lynch syndrome in colorectal cancer patients. | |
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MedLine Citation:
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PMID: 18402524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is the most common form of hereditary colorectal cancer. It is characterized by early onset of colorectal cancer and other extracolonic-associated malignancies. This disorder is inherited in an autosomal dominant pattern and is due to a mutation in one of the DNA mismatch repair genes. Although clinical and molecular understanding of the syndrome has progressed dramatically in the last decade, diagnosis of the syndrome is still a clinical challenge. This review summarizes the main features of the syndrome and provides an update of its management. |
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Authors:
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M Dolores Giráldez; Sergi Castellví-Bel; Francesc Balaguer; Victòria Gonzalo; Teresa Ocaña; Antoni Castells |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Expert review of anticancer therapy Volume: 8 ISSN: 1744-8328 ISO Abbreviation: Expert Rev Anticancer Ther Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-11 Completed Date: 2008-05-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101123358 Medline TA: Expert Rev Anticancer Ther Country: England |
Other Details:
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Languages: eng Pagination: 573-83 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. mgiralde@clinic.ub.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Colorectal Neoplasms, Hereditary Nonpolyposis*
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diagnosis,
genetics,
therapy DNA Mismatch Repair* Genetic Predisposition to Disease* Humans Immunohistochemistry Microsatellite Instability Mutation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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