| Lymphoproliferative disorders after immunosuppressive therapy for aplastic anemia: a case report and literature review. | |
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MedLine Citation:
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PMID: 19295190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 61-year-old Japanese man was referred to our hospital in 2002 due to severe pancytopenia. Bone marrow and peripheral blood findings indicated he had severe aplastic anemia (AA). A whole-body CT scan and Ga scintigraphy revealed no abnormal findings. Antithymocyte globulin and cyclosporine A (CyA) were administered and he got transfusion independently. In September 2004, he complained of abdominal fullness and a skin eruption in the lower abdomen. An abdominal CT revealed a spleen mass and lymphoadenopathy of the pancreas head. Splenectomy was done, and he was diagnosed with a diffuse large B cell lymphoma (DLBCL) of the spleen and skin. His karyotype was associated with t(14; 18). CyA was stopped, all lesions disappeared, and then his AA relapsed. In January 2007, antithymocyte globulin/CyA was readministered. In May 2007, he complained of acute swelling in his right thigh. A biopsy from the tumor revealed DLBCL. CyA was stopped again, yet the lymphoma did not regress. He was given R-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, prednisolone), followed by 5 cycles of R-VP (rituximab, vincristine, prednisolone) and radiation therapy, resulting in a partial remission. We report DLBCL after immunosuppressive therapy for AA. Although this is a rare complication, it should be considered before beginning immunosuppressive therapy. |
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Authors:
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Yuhko Suzuki; Nozomi Niitsu; Miyuki Hayama; Takuji Katayama; Ryuji Ishii; Manabu Osaka; Koji Miyazaki; Mikio Danbara; Ryouichi Horie; Tsutomu Yoshida; Naoya Nakamura; Masaaki Higashihara |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-03-18 |
Journal Detail:
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Title: Acta haematologica Volume: 121 ISSN: 1421-9662 ISO Abbreviation: Acta Haematol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-17 Completed Date: 2009-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM |
Copyright Information:
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(c) 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Hematology, School of Medicine, Kitasato University, Sagamihara, Japan. ysuzuki-hki@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Aplastic
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complications*,
pathology,
therapy Antibodies, Monoclonal / administration & dosage Antilymphocyte Serum / administration & dosage, adverse effects Antineoplastic Combined Chemotherapy Protocols / administration & dosage Asian Continental Ancestry Group Cyclophosphamide / administration & dosage Cyclosporine / administration & dosage, adverse effects Doxorubicin / administration & dosage Humans Immunosuppression / adverse effects* Immunosuppressive Agents / administration & dosage, adverse effects Japan Lymphoma, Large B-Cell, Diffuse / etiology*, pathology, therapy Male Middle Aged Prednisolone / administration & dosage Radionuclide Imaging Radiotherapy / methods Skin Neoplasms / etiology*, pathology, therapy Splenectomy Splenic Neoplasms / etiology*, pathology, therapy Tomography, X-Ray Computed Vincristine / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antilymphocyte Serum; 0/Immunosuppressive Agents; 0/rituximab; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 57-22-7/Vincristine; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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