Document Detail


Lymphoproliferative disorder of the airway of an adolescent without immunodeficiency.
MedLine Citation:
PMID:  15963576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epstein-Barr virus (EBV) is a ubiquitous viral pathogen in humans that has a unique ability to immortalize B-cells. In immunosuppressed individuals, EBV can produce non-neoplastic lymphoproliferative disorders involving various organs. We describe a case report of EBV-associated lymphoproliferative disorder in an immunocompetent 14-year-old male. The case provides a description of EBV-associated lymphoproliferation affecting the upper and lower respiratory tract. The massive submucosal infiltration of B-cells in the lingual tonsils, trachea, and bronchi produced near-complete airway obstruction resulting in tracheotomy. Neither surgical reduction of lingual tonsils nor treatment with steroids was of benefit. An extensive evaluation for immunodeficiency and neoplasia was normal. Treatment with rituximab, an anti-CD20 antibody, resulted in near-complete resolution of the infiltrative process, sufficient to allow decannulation. Rituximab is a treatment option for the rare occurrence of non-neoplastic, EBV-associated, lymphoproliferative disorders.
Authors:
R P Boesch; M Daines; A Kaul; R Cotton; R Amin
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-06-15
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  69     ISSN:  0165-5876     ISO Abbreviation:  Int. J. Pediatr. Otorhinolaryngol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-18     Completed Date:  2006-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1591-4     Citation Subset:  IM    
Affiliation:
Division of Pediatric Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Paul.Boesch@cchmc.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Airway Obstruction / drug therapy,  etiology*
Antibodies, Monoclonal / therapeutic use
Epstein-Barr Virus Infections / diagnosis*,  drug therapy
Humans
Immunocompetence*
Immunologic Factors / therapeutic use
Lymphoproliferative Disorders / diagnosis*,  drug therapy,  virology*
Male
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Immunologic Factors; 0/rituximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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