Document Detail

Lymphoproliferative diseases of the ocular adnexa in Korea.
MedLine Citation:
PMID:  18071120     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the clinical features, treatments, and outcomes of patients with ocular lymphoproliferative disease classified according to the World Health Organization classification and to determine prognostic factors of this disease in South Korea. METHODS: Between March 1, 1995, and December 31, 2005, 128 cases of patients with ocular lymphoid tumors treated at the Samsung Medical Center were retrospectively reviewed. RESULTS: The mean patient age was 46.3 years (range, 1-87 years). The major histopathologic subtypes were mucosa-associated lymphoid tissue (MALT) lymphoma in 96 patients (75.0%), lymphoid hyperplasia in 11 (8.6%), diffuse large B-cell lymphoma in 6 (4.7%), and mantle cell lymphoma in 4 (3.1%). Ocular lymphoproliferative lesions were located in the conjunctiva (53 patients), the eyelid (33 patients), and the orbit (42 patients). Twenty patients had tumor relapses (15.6%), and 9 died of lymphoma during follow-up (7.0%). Regarding the analysis of prognostic factors, most patients with MALT lymphoma evidenced local disease, required local treatment, and exhibited a superior prognosis. CONCLUSIONS: Lymphomas of the MALT type constitute most ocular adnexal lymphoproliferative diseases and occur more frequently in South Korea than in Western countries. Patients with MALT lymphoma have favorable outcomes compared with patients with other types of lymphoma.
Dong-Eun Oh; Yoon-Duck Kim
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  125     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-11     Completed Date:  2008-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1668-73     Citation Subset:  AIM; IM    
Department of Ophthalmology, Seoul Veterans Hospital, 50 Ilwon-dong, Kangnam-gu, Seoul 135-710, South Korea.
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MeSH Terms
Aged, 80 and over
Antineoplastic Agents / therapeutic use
Child, Preschool
Combined Modality Therapy
Conjunctival Neoplasms / epidemiology*,  pathology,  therapy
Eyelid Neoplasms / epidemiology*,  pathology,  therapy
Korea / epidemiology
Lymphoma, B-Cell, Marginal Zone / epidemiology*,  pathology,  therapy
Lymphoma, Large B-Cell, Diffuse / epidemiology*,  pathology,  therapy
Lymphoma, Mantle-Cell / epidemiology*,  pathology,  therapy
Middle Aged
Neoplasm Recurrence, Local
Orbital Neoplasms / epidemiology*,  pathology,  therapy
Pseudolymphoma / epidemiology*,  pathology,  therapy
Retrospective Studies
Survival Rate
Reg. No./Substance:
0/Antineoplastic Agents

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