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Lymphoplasmacytic sclerosing pancreato-cholangitis: a case report and review of the literature.
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MedLine Citation:
PMID:  15989743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autoimmune pancreatitis is a rare but important cause of pancreatitis that is becoming increasingly recognized in the West. Lymphoplasmacytic sclerosing pancreatitis (LPSP) is a benign form of chronic pancreatitis characterized clinically by infrequent attacks of abdominal pain, jaundice, and weight loss, and pathologically by focal or diffuse chronic or lymphoplasmacytic inflammatory infiltrates centered around pancreatic ducts and ductules, accompanied by obliterative phlebitis, acinar atrophy, and interstitial fibrosis. It has been described alone or as a part of the spectrum of autoimmune gallbladder and biliary tract disease, with clinical, radiological, and pathological overlap reported with primary sclerosing cholangitis. It has been described as "primary sclerosing pancreatitis," "sclerosing cholangitis," "non-alcoholic duct destructive chronic pancreatitis," and "autoimmune pancreatitis." We report a case of LPSP that mimicked pancreatic adenocarcinoma and was subsequently treated with a pylorus-preserving Whipple procedure. This may point towards a primary biliary autoimmune process involving the pancreatic duct, causing a benign form of chronic pancreatitis that may be difficult to characterize pre-operatively to avoid surgery. This case typifies the growing awareness of this relatively recently characterized clinical entity, its similar presentation to pancreatic carcinoma, and the importance for LPSP to be included in the differential diagnosis of pancreaticobiliary disease. Finally, we review the literature.
Authors:
Priyajit Prasad; Ronald R Salem; Rakhee Mangla; Harry Aslanian; Dhanpat Jain; Jeffrey Lee
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Yale journal of biology and medicine     Volume:  77     ISSN:  1551-4056     ISO Abbreviation:  Yale J Biol Med     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2005-07-01     Completed Date:  2006-05-05     Revised Date:  2009-05-14    
Medline Journal Info:
Nlm Unique ID:  0417414     Medline TA:  Yale J Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cholangitis, Sclerosing / diagnosis*,  pathology
Fibrosis
Humans
Male
Pancreatic Ducts / pathology
Pancreatitis / diagnosis*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Yale J Biol Med
Journal ID (pmc): yjbm
ISSN: 0044-0086
ISSN: 1551-4056
Publisher: Yale Journal of Biology and Medicine
Article Information
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Print publication date: Month: 9 Year: 2004
Volume: 77 Issue: 5-6
First Page: 143 Last Page: 148
ID: 2259126
PubMed Id: 15989743

Lymphoplasmacytic sclerosing pancreato-cholangitis: a case report and review of the literature.
Priyajit Prasad
Ronald R. Salem
Rakhee Mangla
Harry Aslanian
Dhanpat Jain
Jeffrey Lee
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.


Article Categories:
  • Research Article


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