Document Detail


Lymphoplasmacyte-rich meningioma mimicking idiopathic hypertrophic pachymeningitis.
MedLine Citation:
PMID:  17548990     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 24-year-old man presented with long-term headache and progressive visual loss. Neuro-ophthalmic manifestations included finger counting acuity in both eyes, weakly reactive pupils, pale optic discs, and increased deep tendon reflexes. Brain MRI showed meningeal thickening that involved the optic nerves and chiasm and enveloped and displaced the brainstem as far caudally as the foramen magnum. The diffuse extensive nature of the lesion suggested an inflammatory process such as idiopathic hypertrophic pachymeningitis (IHP), but anterior temporal brain biopsy disclosed a relatively high proportion of meningothelial cells with islands of polyclonal inflammatory reaction consistent with a diagnosis of lymphoplasmacyte-rich meningioma (LRM), a rare variant. Among the 19 reported cases of LRM, none has shown as extensive a mass as seen in our patient. Distinguishing between LRM and IHP is important because these entities are treated differently.
Authors:
Parima Hirunwiwatkul; Jonathan D Trobe; Mila Blaivas
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society     Volume:  27     ISSN:  1070-8022     ISO Abbreviation:  J Neuroophthalmol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-08-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431308     Medline TA:  J Neuroophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-4     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Diagnosis, Differential
Dura Mater / pathology*
Humans
Hypertrophy
Magnetic Resonance Imaging
Male
Meningeal Neoplasms / diagnosis*
Meningioma / diagnosis*
Meningitis / diagnosis*
Plasma Cells / pathology*
Comments/Corrections
Comment In:
J Neuroophthalmol. 2007 Jun;27(2):89-90   [PMID:  17548989 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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