Document Detail


Lymphopenia as a prognostic factor in patients with peripheral T-cell lymphoma, unspecified.
MedLine Citation:
PMID:  20849388     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Peripheral T-cell lymphoma, unspecified (PTCLU) is the most common T-cell lymphoma variant. The molecular heterogeneity of PTCLU is reflected by a diverse clinical course. Several prognostic factors have been studied, but further refinement is needed. The aim of our study was to retrospectively evaluate the presence of lymphopenia, defined as a lymphocyte count of<1000 cells/mm³, as a prognostic factor for survival in patients with PTCLU. Sixty-nine cases with a pathological diagnosis of PTCLU were included in our analysis. Lymphopenia was seen in 38% of the patients and was statistically associated with a worse response to chemotherapy. In univariate analysis, lymphopenia, IPI score>2, and Prognostic Index for PTCLU (PIT) score>2 were associated with a worse overall survival. In multivariate analysis, lymphopenia and a PIT score>2 were the only independent poor prognostic factors, implying an important role of the patient's immune system in both response to therapy and survival.
Authors:
Jorge J Castillo; Domingo Morales; Pilar Quinones; Esther Cotrina; Carlos Desposorio; Brady Beltran
Related Documents :
10215438 - Prediction of the survival of patients with advanced ovarian cancer according to a risk...
9337678 - Prognostic factors for patients with advanced seminoma treated with platinum-based chem...
23172518 - The chemotherapy long-term effect on cognitive functions and brain metabolism in lympho...
20001488 - Pattern of spread and prognosis in lower limb-onset als.
9349888 - Trigger finger: the effect of partial release of the first annular pulley on triggering.
10073568 - High-dose chemotherapy in adult sarcomas: no standard yet.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  51     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  1822-8     Citation Subset:  IM    
Affiliation:
The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI, USA. jcastillo@lifespan.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections
Comment In:
Leuk Lymphoma. 2010 Oct;51(10):1773-4   [PMID:  20849382 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Protein kinase networks regulating glucocorticoid-induced apoptosis of hematopoietic cancer cells: f...
Next Document:  Bacterial invasion of eukaryotic cells can be mediated by actin-hydrolysing metalloproteases grimely...