| Lymphomatoid papulosis: Clinical and pathological findings in 18 patients. | |
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MedLine Citation:
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PMID: 22261676 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Lymphomatoid papulosis (LyP) is a CD30(+) lymphoproliferative skin disease that has been described in association with Hodgkin lymphoma. It has also been reported to progress to mycosis fungoides or cutaneous anaplastic large-cell lymphoma. OBJECTIVE: To study the clinical and histologic features of LyP and response to treatment in a patient series. MATERIALS AND METHODS: For this retrospective, descriptive, observational study of patients with histologically confirmed LyP and sufficient follow-up data on record, we extracted histologic findings on skin biopsy, clinical presentation, clinical course, and response to treatments. RESULTS: Eighteen patients (10 male, 8 female) were identified. Most biopsies (14/18, 78%) showed a wedge-shaped lymphocytic infiltrate with CD30(+), CD3(+), and CD56(-) cells. A type A histologic pattern was present in the biopsies of 83% of the patients. The most common presentation (83%) consisted of papules on the trunk; for 62% LyP resolved after a single episode. Twelve percent of the patients developed mycosis fungoides (mean follow-up, 7 years); no other associations were noted. DISCUSSION: Although few series of patients with LyP have been published in recent years, the findings reported generally coincide with our observations. CONCLUSION: LyP is typically a CD30(+) lymphoproliferative disorder that usually runs a benign course and responds well to treatment. |
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Authors:
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M Fernández-Guarino; R Carrillo-Gijón; P Jaén-Olasolo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
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Title: Actas dermo-sifiliograficas Volume: - ISSN: 1578-2190 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373062 Medline TA: Actas Dermosifiliogr Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier España, S.L. y AEDV. All rights reserved. |
Affiliation:
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Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, España. |
Vernacular Title:
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Papulosis linfomatoide: hallazgos clínico-patológicos en 18 pacientes. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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