| Lymphomas of the female genital tract: a study of 186 cases and review of the literature. | |
| | |
MedLine Citation:
|
PMID: 16224219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Malignant lymphomas in the female genital tract are rare, and those arising from this tissue system are extremely uncommon. Most pertinent reports lack clear references to the accepted classifications or failed to apply immunomarkers and molecular techniques for a reliable diagnosis. We analyzed a large group of patients with primary and secondary lymphomas of the female genital tract classified on the basis of the recent WHO consensus. A total of 186 patients with malignant lymphoma detected in the female genital tract were selected from the files of the Kiel Lymphoma Registry covering the period of 1974 to 2004. Stringent criteria were applied to separate systemic versus secondary lymphomas. All cases were reviewed on the basis of conventionally stained sections, relevant immunohistochemistry using the alkaline phosphatase/anti-alkaline phosphatase technique, and clinical information, as far as available. When required, gene rearrangement analysis was performed, including TCR-gamma chain gene and the three FR fragments of the IgG heavy chain gene. In addition, typical chromosomal translocations were detected by means of the FISH technique to verify the diagnosis, where needed. Thirty-seven percent of the cases were systemic lymphomas and 63% were mostly extranodal lymphomas primary to the female genital tract. The adnexa were involved in 87 cases, followed by uterine corpus in 23 cases, uterine cervix in 17 cases, portio in 9 cases, vagina in 11 cases, and vulva including clitoris in 8 cases. In 31 cases, two or more adjacent sites were involved. In both (primary and secondary) groups, the adnexa were the prevailing site of involvement. As expected, the overwhelming majority of cases were of B phenotype. The most frequent type of lymphoma proved to be diffuse large B-cell lymphoma, closely followed by follicular lymphoma, including all 3 grades of malignancy. Burkitt lymphoma showed a rather similar frequency. Marginal zone lymphoma occurred exclusively as primary lesions in the uterine mucosa. Lymphoplasmacytic lymphoma was restricted to the vulvo-vaginal area and occurred in women over 60 years of age. In conclusion, our study provides a thorough overview of various types of lymphoma affecting the female genital tract primarily or secondarily, which were classified on the basis of a widely accepted WHO classification. Although quite rare, our report should remind the pathologist of considering malignant lymphomas while reading biopsies taken from female genital organ. |
| | |
Authors:
|
Farid Kosari; Yahya Daneshbod; Reza Parwaresch; Matias Krams; Hans-Heinrich Wacker |
Related Documents
:
|
9168449 - Aggressive natural killer (nk) cell lymphoma: report of a pediatric case and review of ... 20199449 - Primary cutaneous cd30 positive anaplastic large cell lymphoma in an adolescent. 7724249 - Four cases of spuriously low wbc count due to in vitro leukocyte agglutination: contrib... 20807089 - Ocular adnexal mucosa-associated lymphoid tissue lymphoma in northern china: high frequ... 11939739 - Spontaneous regression of kikuchi lymphadenopathy with oligoclonal t-cell populations f... 3707029 - Pulmonary lymphoma or pseudolymphoma: a diagnostic dilemma. 1557949 - Peroneal muscular atrophy with hereditary spastic paraparesis (hmsn v) is pathologicall... 11577119 - Evidence for antibiotic induced clostridium perfringens diarrhoea. 17652529 - Mismatch repair genes hmlh1 and hmsh2 may not play an essential role in breast carcinog... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The American journal of surgical pathology Volume: 29 ISSN: 0147-5185 ISO Abbreviation: Am. J. Surg. Pathol. Publication Date: 2005 Nov |
Date Detail:
|
Created Date: 2005-10-14 Completed Date: 2006-01-31 Revised Date: 2006-10-13 |
Medline Journal Info:
|
Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 1512-20 Citation Subset: IM |
Affiliation:
|
Tehran University of Medical Sciences, Tehran, Iran. faridkosari@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Female Genital Neoplasms, Female / pathology* Humans Infant Lymphoma / pathology* Middle Aged Retrospective Studies |
| Comments/Corrections | |
Comment In:
|
Am J Surg Pathol. 2006 Sep;30(9):1202-3
[PMID:
16931968
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analytical validation and interobserver reproducibility of EnzMet GenePro: a second-generation brigh...
Next Document: Focal changes of chronic pancreatitis and duct-arteriovenous relationships: avoiding a diagnostic pi...