Document Detail


Lymphoma and leukemia manifested by steroid-responsive polyneuropathy.
MedLine Citation:
PMID:  6311144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Subacute polyneuropathy that responded to prednisone was the initial symptom in two patients, one of whom was later found to have histiocytic lymphoma and the other, chronic lymphocytic leukemia. Sural nerve biopsy specimens in both showed extensive segmental demyelination. In the first patient, there was invasion of the myelinated axons by macrophage processes, and the later course of the neuropathy appeared to parallel that of the lymphoma. In the second patient, there was diffuse lymphocytic infiltration of the perineurium and endoneurium, lymphocytes were found beneath the basal lamina, and the demyelination was characterized by extensive vesicular degeneration of the myelin sheath. The demyelination appeared to be cell mediated in the first patient. This was probably the mechanism in the second patient as well, but simple mechanical compression by infiltrating leukemic cells was another possible explanation.
Authors:
S M Sumi; D F Farrell; T A Knauss
Related Documents :
141974 - The effect of thymosin on patients with disseminated malignancies. a phase i study.
6449824 - Lymphocyte atpase activity in patients with carcinoma of the larynx. a follow-up study ...
11579714 - Subclinical pulmonary involvement assessed by bronchoalveolar lavage in patients with e...
396664 - Phase ii trial of prednimustine. leo-1031 (nsc-134087) in acute non-lymphocytic leukemia.
10561764 - The outcome of trial off catheter after acute retention of urine.
3592814 - Surgical intervention in neonates with critical pulmonary stenosis.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  40     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  577-82     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chronic Disease
Humans
Leukemia, Lymphoid / complications*
Lymphatic Diseases / complications*
Lymphoma / complications*
Male
Middle Aged
Neoplasms
Peripheral Nervous System Diseases / drug therapy,  etiology*,  pathology
Prednisone / therapeutic use*
Chemical
Reg. No./Substance:
53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of a bran diet on the total passage rate and tract measurements in weanling swine
Next Document:  Ciliary body and choroidal melanomas treated by proton beam irradiation. Histopathologic study of ey...