Document Detail


Lympholeukemia in madai Pagrus major in Japan.
MedLine Citation:
PMID:  10782349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lympholeukemia has been occurring to an epizootic extent with mass mortality in 1 and 2 yr old madai (= Japanese red sea bream) Pagrus major in the winter season (October-May) in the western regions of Japan since 1975. Diseased fish displayed severe anemia and markedly increased numbers of neoplastic lymphocytoid and lymphoblastoid cells in the blood. Neoplastic cells originated in the splenic lymphatic cells and systemically caused severe metastatic lesions in the heart, liver, kidney, digestive tracts, gills and the lateral musculature. Electron microscopy revealed adeno-like viral particles (78 to 83 nm in diameter) in the nucleus of lymphoblastoid cells which appeared in the early prevalent stage but no viral particles in the lymphocytoid cells or plasmacytoid cells, which subsequently increased in number. In this paper, we describe light and electron microscopic features of neoplasms and neoplastic cells.
Authors:
T Miyazaki; Y Asai; T Kobayashi; M Miyata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diseases of aquatic organisms     Volume:  40     ISSN:  0177-5103     ISO Abbreviation:  Dis. Aquat. Org.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-23     Completed Date:  2000-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8807037     Medline TA:  Dis Aquat Organ     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  147-55     Citation Subset:  IM    
Affiliation:
Faculty of Bioresources, Mie University, Japan. miyazaki@bio.mie-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Fish Diseases / etiology*,  pathology
Japan
Leukemia, Lymphoid / pathology,  veterinary*
Microscopy, Electron
Perciformes
Virion / ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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