Document Detail

Lymphokine-activated killer traffic assay and our preliminary clinical results of regional arterial infusion of lymphokine-activated killer cells for renal cell carcinoma.
MedLine Citation:
PMID:  1949369     Owner:  NLM     Status:  MEDLINE    
In vivo distribution of radiolabeled lymphokine-activated killer (LAK) cells that were administered either through the caudal vein or the abdominal aorta of Lewis rats was studied. The LAK traffic study showed remarkable increase in radioactivity in several organs peripheral to the arterial injection site. We began treating the patients with metastatic renal cancer by means of regional arterial administration of LAK cells. This treatment was supported by the results of the traffic assay. Our regional LAK therapy, which involves a weekly leukapheresis in combination with daily systemic low dose interleukin-2 administration, has been in practice for over 2.5 years. Seven out of 12 metastatic lesions in the 7 patients treated showed regression. Two responding cases have been alive for over 2 years. Responding lesions were bone, muscle, para-aortic lymph node, and/or retroperitoneum. The regional arterial administration of LAK cells is local therapy. However, this mode of therapy could be useful for those patients with extrapulmonary nonresectable metastasis and at least one injectable feeding artery. This study shows our laboratory data concerning the localization of LAK cells transferred via arterial route and our clinical cases treated with regional arterial administration of LAK cells.
M Hayakawa; Y Koyama; R D Williams; A Osawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Urologia internationalis     Volume:  47 Suppl 1     ISSN:  0042-1138     ISO Abbreviation:  Urol. Int.     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-29     Completed Date:  1991-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  127-31     Citation Subset:  IM    
University of the Ryukyus, Okinawa, Japan.
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MeSH Terms
Carcinoma, Renal Cell / therapy*
Immunotherapy, Adoptive*
Infusions, Intra-Arterial
Iodine Radioisotopes / diagnostic use
Kidney Neoplasms / therapy*
Killer Cells, Lymphokine-Activated / immunology*,  transplantation
Middle Aged
Rats, Inbred Lew
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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