| Lymphoid preponderance and the absence of basophilia and splenomegaly are frequent in m-bcr-positive chronic myelogenous leukemia. | |
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MedLine Citation:
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PMID: 11976825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic myelogenous leukemia (CML) with a minor bcr-abl transcript is a rare entity. We describe a 66-year-old female who was diagnosed with CML in the chronic phase. Molecular analysis of her Philadelphia chromosome using the reverse transcriptase polymerase chain reaction and subsequent sequencing revealed a minor bcr-abl transcript. Monocytosis resembling chronic myelomonocytic leukemia was observed without splenomegaly and basophilia. Her clinical course was indolent and maintained the chronic phase of CML for nearly 3 years under hydroxyurea treatment. A review of the 23 cases of m-bcr CML including this case showed the presence of monocytosis and the absence of basophilia and splenomegaly in 55.0%, 55.0%, and 70.0% of patients, respectively. The absence of basophilia was a significant finding in patients without monocytosis ( P=0.01). Although the hematological features or clinical outcomes were variable in m-bcr CML cases, all three cases at the onset of the blastic phase showed lymphoid crisis, implying an increased lymphoid leukemogenicity of minor bcr-abl transcripts. |
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Authors:
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M Hur; E Y Song; S-H Kang; D-H Shin; J Y Kim; S S Park; H I Cho |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2002-02-28 |
Journal Detail:
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Title: Annals of hematology Volume: 81 ISSN: 0939-5555 ISO Abbreviation: Ann. Hematol. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-26 Completed Date: 2002-07-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: Germany |
Other Details:
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Languages: eng Pagination: 219-23 Citation Subset: IM |
Affiliation:
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Department of Clinical Pathology, Seoul National University College of Medicine, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Basophils / cytology Female Fusion Proteins, bcr-abl / genetics* Humans Hydroxyurea / administration & dosage Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood, genetics, pathology* Leukocytosis / blood* Monocytes / cytology Polymerase Chain Reaction RNA, Messenger / analysis Splenomegaly |
| Chemical | |
Reg. No./Substance:
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0/Fusion Proteins, bcr-abl; 0/RNA, Messenger; 127-07-1/Hydroxyurea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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