Document Detail


Lymphoid preponderance and the absence of basophilia and splenomegaly are frequent in m-bcr-positive chronic myelogenous leukemia.
MedLine Citation:
PMID:  11976825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic myelogenous leukemia (CML) with a minor bcr-abl transcript is a rare entity. We describe a 66-year-old female who was diagnosed with CML in the chronic phase. Molecular analysis of her Philadelphia chromosome using the reverse transcriptase polymerase chain reaction and subsequent sequencing revealed a minor bcr-abl transcript. Monocytosis resembling chronic myelomonocytic leukemia was observed without splenomegaly and basophilia. Her clinical course was indolent and maintained the chronic phase of CML for nearly 3 years under hydroxyurea treatment. A review of the 23 cases of m-bcr CML including this case showed the presence of monocytosis and the absence of basophilia and splenomegaly in 55.0%, 55.0%, and 70.0% of patients, respectively. The absence of basophilia was a significant finding in patients without monocytosis ( P=0.01). Although the hematological features or clinical outcomes were variable in m-bcr CML cases, all three cases at the onset of the blastic phase showed lymphoid crisis, implying an increased lymphoid leukemogenicity of minor bcr-abl transcripts.
Authors:
M Hur; E Y Song; S-H Kang; D-H Shin; J Y Kim; S S Park; H I Cho
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2002-02-28
Journal Detail:
Title:  Annals of hematology     Volume:  81     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-26     Completed Date:  2002-07-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  219-23     Citation Subset:  IM    
Affiliation:
Department of Clinical Pathology, Seoul National University College of Medicine, Korea.
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MeSH Terms
Descriptor/Qualifier:
Aged
Basophils / cytology
Female
Fusion Proteins, bcr-abl / genetics*
Humans
Hydroxyurea / administration & dosage
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood,  genetics,  pathology*
Leukocytosis / blood*
Monocytes / cytology
Polymerase Chain Reaction
RNA, Messenger / analysis
Splenomegaly
Chemical
Reg. No./Substance:
0/Fusion Proteins, bcr-abl; 0/RNA, Messenger; 127-07-1/Hydroxyurea

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