Document Detail


Lymphoid malignancies: many tumor types, many altered genes, many therapeutic challenges.
MedLine Citation:
PMID:  23023709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lymphoid tissues, including both the B and T cell lineages, are characterized by a unique level of biological complexity due to the anatomical organization of functionally distinct cell subpopulations and complex processes of genetic alteration required to generate immune responses. Not surprisingly, this physiological diversity and complexity is mirrored by the broad spectrum of malignancies derived from lymphocytes. The articles in this Review Series highlight recent progress in selected common lymphoid malignancies, with a focus on the genetic alterations that drive malignant transformation, including those identified by genome-wide analyses. These genetic alterations represent the basis from which cellular pathways of therapeutic relevance can be identified, studied, and eventually targeted.
Authors:
Riccardo Dalla-Favera
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Publication Detail:
Type:  Introductory Journal Article     Date:  2012-10-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3396-7     Citation Subset:  AIM; IM    
Affiliation:
Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA. rd10@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Humans
Leukemia, Lymphoid* / etiology,  genetics,  pathology,  therapy
Lymphoma* / etiology,  genetics,  pathology,  therapy
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