| Lymphoid follicles of different phenotype appear in ileum during involution of the sheep ileal Peyer's patch. | |
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MedLine Citation:
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PMID: 15752550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ileal Peyer's patch (IPP) of young sheep is a site of diversification of the primary antibody repertoire and where involution takes place at young age. Tissue samples from the ileum were collected in 134 animals aged from 1 month to 6 years, and IPP follicle phenotypes were characterised. We describe a new type of ileal lymphoid follicles that became relatively more frequent during involution, and had numerous intrafollicular T-cells and BAQ44A+ B-cells and large interfollicular T-cell areas. As opposed to classical IPP follicles in which the BAQ44A+ cells were confined to the narrow follicle-neck region, the novel atypical ileal lymphoid follicle had these cells distributed throughout the follicle. The relative distribution of cell types in the typical IPP follicle remained fairly constant during involution. Many animals older than 9 months (64/92) still had had typical IPP follicles and even sheep 4 years and older (5/9) had IPP-type follicles. |
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Authors:
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Kai-Inge Lie; Mona Aleksandersen; Thor Landsverk |
Publication Detail:
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Type: Journal Article Date: 2004-12-24 |
Journal Detail:
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Title: Developmental and comparative immunology Volume: 29 ISSN: 0145-305X ISO Abbreviation: Dev. Comp. Immunol. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-03-08 Completed Date: 2005-07-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708205 Medline TA: Dev Comp Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 539-53 Citation Subset: IM |
Affiliation:
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Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, P.O. Box 8146 Dep., Oslo N-0033, Norway. kai.lie@veths.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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5'-Nucleotidase
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analysis Animals B-Lymphocytes / cytology, immunology* Carbonic Anhydrases / analysis Cell Size Ileum / cytology, enzymology, immunology* Immunohistochemistry / veterinary Immunophenotyping / veterinary Peyer's Patches / cytology, enzymology, immunology* Sheep / immunology* T-Lymphocytes / cytology, immunology* Video Recording |
| Chemical | |
Reg. No./Substance:
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EC 3.1.3.5/5'-Nucleotidase; EC 4.2.1.1/Carbonic Anhydrases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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