Document Detail

Lymphoid cell populations in splenectomized and nonsplenectomized SJL/J mice bearing Hodgkin's disease-like reticulum cell sarcoma.
MedLine Citation:
PMID:  2947988     Owner:  NLM     Status:  MEDLINE    
Using the reticulum cell sarcoma (RCS) of the SJL/J mouse as a model for Hodgkin's disease, the effects of tumor growth and splenectomy on the T-cell and B-cell populations were evaluated. Although splenectomy improved survival and reduced gross observable tumor growth in secondary tumor sites, no effect on T-cell and B-cell populations was detected. We conclude that tumor growth appears to be undetected by the immune system; previously reported immunosuppression in RCS-bearing mice must be due to functional changes and not cell population changes; and splenectomy contributes to survival and suppression of tumor cell growth in secondary sites.
S P Brooks; G A Rich; Y S Huh; D R Cooney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  21     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-02-17     Completed Date:  1987-02-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1114-8     Citation Subset:  IM    
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MeSH Terms
B-Lymphocytes / immunology
Disease Models, Animal
Hodgkin Disease / immunology*,  pathology
Leukocyte Count
Lymphocytes / immunology*
Lymphoma, Non-Hodgkin / immunology*,  pathology
Mice, Inbred Strains
Monocytes / immunology
Neoplasm Transplantation
T-Lymphocytes, Helper-Inducer / immunology
T-Lymphocytes, Regulatory / immunology

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