Document Detail

Lymphoepithelioma-like carcinoma of the skin: a report of 3 Epstein-Barr virus (EBV)-negative additional cases. Immunohistochemical study of the stroma reaction.
MedLine Citation:
PMID:  10885408     Owner:  NLM     Status:  MEDLINE    
Lymphoepithelial carcinoma is a relatively common malignancy in the nasopharynx, but it rarely occurs in other sites. We report 3 additional cases of cutaneous location. Histopathologically, the tumors consisted of multiple well-circumscribed dermal-hypodermal nodules composed of aggregates of undifferentiated malignant cells. These cells had moderate amounts of eosinophilic cytoplasm and vesicular nuclei with prominent nucleoli. There was no squamous or glandular differentiation. For each case, a heavy lymphoplasmacytic infiltrate was found. No dysplasia was noted in the epidermis. In one case, the tumoral component showed numerous Sternberg-like cells scattered within a lymphocytic background. This case might be mistaken with a Hodgkin's lymphoma. Immunohistochemistry showed that the neoplastic cells were positive for cytokeratin and epithelial membrane antigen. In the present report, studying the stroma reaction cell components, we have stressed the presence of numerous factor XIIIa-positive dendritic cells in 2 cases. Because of the role of these cells in the immune response of normal stroma, their presence herein might be in relation with the favorable prognosis of this type of primary skin carcinoma. No Epstein-Barr viral genomic sequences were detected by in situ hybridization. This negativity for Epstein-Barr virus may be a help in the differential diagnosis from metastatic undifferentiated nasopharyngeal carcinoma.
S Ferlicot; F Plantier; L Rethers; A D Bui; J Wechsler
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  27     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-10-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  306-11     Citation Subset:  IM    
Département de Pathologie, Hôpital Henri-Mondor AP-HP, Créteil, France.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / chemistry,  pathology*,  virology
Herpesvirus 4, Human / isolation & purification*
Immunoenzyme Techniques
In Situ Hybridization
Middle Aged
Neoplasm Proteins / analysis
Skin / chemistry,  pathology*
Skin Neoplasms / chemistry,  pathology*,  virology
Stromal Cells / chemistry,  pathology*
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Neoplasm Proteins; 0/Tumor Markers, Biological

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