Document Detail


Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature.
MedLine Citation:
PMID:  20952226     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare tumor of unknown etiology, low malignant potential, and microscopic resemblance to undifferentiated nasopharyngeal carcinoma. Clinically, it presents as a flesh-colored firm nodule or plaque on the face, scalp, or shoulder of middle-aged to elderly individuals. Histologically, LELCS is composed of islands of enlarged epithelial cells with large vesicular nuclei surrounded and permeated by a dense lymphoplasmacytic infiltrate. LELCS exhibits immunoreactivity with high-molecular-weight cytokeratins and epithelial membrane antigen, indicating the epithelial origin. The differential diagnosis includes basal cell carcinoma, squamous cell carcinoma, lymphoma, pseudolymphoma, and Merkel cell carcinoma. We report 11 cases of LELCS of the head and neck region with discussion of the clinical, histopathologic, immunohistochemical, and therapeutic aspects of this rare cutaneous neoplasm. In addition, we systematically review and compare the findings with the previously published cases of LELCS. This study is the largest case series of LELCS reported in the English-language literature. It attempts to more clearly define the diagnostic criteria for LELCS. Its histomorphologic and immunophenotypic features help distinguish this tumor from similar-appearing malignancies, including metastatic nasopharyngeal carcinoma.
Authors:
Preston Q Welch; Stephen B Williams; Robert D Foss; Maria-Magdalena Tomaszewski; Anish Gupta; Junu Ojha
Related Documents :
16360826 - Epithelial-myoepithelial carcinoma in the base of the tongue: a case report.
24661806 - Nosocomial tuberculosis exposures at a tertiary care hospital: a root cause analysis.
9471086 - Basal-cell carcinoma of the finger: a case report and review of the literature.
19640316 - Extra-pulmonary small cell carcinoma of the neopharynx: case report and review of neoph...
22026316 - Methodology for the systematic reviews on occupational therapy for adults with alzheime...
2758196 - The reverse flow ulnar artery island flap: 42 clinical cases.
Publication Detail:
Type:  Journal Article     Date:  2010-10-16
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  111     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  78-86     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Affiliation:
Wiesbaden Dental Clinic Command, Wiesbaden, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Simvastatin-loaded porous implant surfaces stimulate preosteoblasts differentiation: an in vitro stu...
Next Document:  Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus.