Document Detail

Lymphoepithelial cyst and epidermoid cyst of the accessory spleen in the pancreas.
MedLine Citation:
PMID:  9872647     Owner:  NLM     Status:  MEDLINE    
We report here two rare cystic lesions, a lymphoepithelial cyst (LEC) and an epidermoid cyst of the accessory spleen (ECAS) occurring in the pancreas. Histologically, the LEC was lined by stratified squamous epithelium and surrounded by a layer of lymphoid tissue with germinal centers. The ECAS showed similar histologic features with scattered lymphoid tissue, but splenic pulp tissue was present in the wall. In both cysts, some small pancreatic islets and ducts were seen in the fibrous tissue surrounding the lymphoid layer or the splenic pulp, respectively. The lining epithelia of the LEC and the ECAS, as well as those of retention cysts of the pancreas and epidermoid cysts of the spleen used for comparison, were similarly positive with AE1/3, CAM5.2, CK7, CK13, and carcinoembryonic antigen. CA19-9 was also detected in the epithelial cells of the LEC, the ECAS, and the retention cyst of the pancreas, but not in those of the splenic epidermoid or branchial cleft cysts used for comparison. These findings indicate that LECs and ECASs might develop from the pancreatic ducts protruding into a lymph node or accessory spleen located in the pancreas, respectively. Some of both cysts might cause elevated levels of serum carcinoembryonic antigen and/or CA19-9 and should be distinguished from malignant cystic tumors.
H Tateyama; T Tada; T Murase; S Fujitake; T Eimoto
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  11     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-10     Completed Date:  1999-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1171-7     Citation Subset:  IM    
Department of Pathology, Nagoya City University Medical School, Nagoya, Japan.
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MeSH Terms
Antibodies, Monoclonal
Carcinoembryonic Antigen / metabolism
Choristoma / metabolism,  pathology*,  surgery
Cysts / metabolism,  pathology,  surgery
Epidermal Cyst / metabolism,  pathology*,  surgery
Epithelial Cells / metabolism,  pathology*
Immunoenzyme Techniques
Keratins / metabolism
Lymphoid Tissue / metabolism,  pathology*,  surgery
Middle Aged
Splenic Diseases / metabolism,  pathology*,  surgery
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Carcinoembryonic Antigen; 68238-35-7/Keratins

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