| Lymphocytotoxic antibodies in primary biliary cirrhosis. | |
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MedLine Citation:
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PMID: 3875464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sera of 30 patients with primary biliary cirrhosis (PBC) and 72 normal subjects matched for age and sex were examined for the presence of lymphocytotoxic antibodies (LCAs) against B and T cells at 4 degrees C and 37 degrees C. Patients were prospectively screened for: Sjögren's syndrome, scleroderma, Hashimoto's thyroiditis, and rheumatoid arthritis, in which LCAs have been described. Seventeen patients with PBC (56.6%) had LCAs against B cells as compared with only 11 of the 72 normal subjects (P less than 0.001). Five PBC patients (16.6%) also reacted against T cells as compared with none in control group (P less than 0.01). Clinical and biochemical features and the histological stage of PBC were similar in patients with and without LCA. Sjögren's syndrome was present in 13 patients--two with scleroderma and another with Hashimoto's thyroiditis. No patient had rheumatoid arthritis. The prevalence of LCAs was similar in PBC patients with or without autoimmune associated disease (54% vs 59%). We conclude that in PBC a high incidence of LCA is unrelated to the presence of an associated disease. LCA in PBC might be a nonspecific marker of an immune disorder. |
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Authors:
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A Parés; J Martorell; J Caballería; J Vives; M Bruguera; J Rodés |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 30 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1985-10-04 Completed Date: 1985-10-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 829-33 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antilymphocyte Serum / analysis* B-Lymphocytes / immunology Female Humans Liver Cirrhosis, Biliary / complications, immunology* Male Middle Aged Sjogren's Syndrome / complications, immunology T-Lymphocytes / immunology Thyroiditis, Autoimmune / complications, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antilymphocyte Serum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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