Document Detail

Lymphocytotoxic antibodies in primary biliary cirrhosis.
MedLine Citation:
PMID:  3875464     Owner:  NLM     Status:  MEDLINE    
Sera of 30 patients with primary biliary cirrhosis (PBC) and 72 normal subjects matched for age and sex were examined for the presence of lymphocytotoxic antibodies (LCAs) against B and T cells at 4 degrees C and 37 degrees C. Patients were prospectively screened for: Sjögren's syndrome, scleroderma, Hashimoto's thyroiditis, and rheumatoid arthritis, in which LCAs have been described. Seventeen patients with PBC (56.6%) had LCAs against B cells as compared with only 11 of the 72 normal subjects (P less than 0.001). Five PBC patients (16.6%) also reacted against T cells as compared with none in control group (P less than 0.01). Clinical and biochemical features and the histological stage of PBC were similar in patients with and without LCA. Sjögren's syndrome was present in 13 patients--two with scleroderma and another with Hashimoto's thyroiditis. No patient had rheumatoid arthritis. The prevalence of LCAs was similar in PBC patients with or without autoimmune associated disease (54% vs 59%). We conclude that in PBC a high incidence of LCA is unrelated to the presence of an associated disease. LCA in PBC might be a nonspecific marker of an immune disorder.
A Parés; J Martorell; J Caballería; J Vives; M Bruguera; J Rodés
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  30     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-10-04     Completed Date:  1985-10-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  829-33     Citation Subset:  AIM; IM    
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MeSH Terms
Antilymphocyte Serum / analysis*
B-Lymphocytes / immunology
Liver Cirrhosis, Biliary / complications,  immunology*
Middle Aged
Sjogren's Syndrome / complications,  immunology
T-Lymphocytes / immunology
Thyroiditis, Autoimmune / complications,  immunology
Reg. No./Substance:
0/Antilymphocyte Serum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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