| Lymphocytic infiltration and expression of inducible nitric oxide synthase in human duodenal and colonic mucosa is a characteristic feature of ankylosing spondylitis. | |
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MedLine Citation:
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PMID: 14677189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In patients with ankylosing spondylitis (AS), inflammatory processes have been detected in the ileal and colonic mucosa. The inducible isoform of nitric oxide synthase (iNOS) may be expressed early in the inflammatory process. We investigated iNOS activity and lymphocytic infiltration in the duodenum and colon in patients with AS and ulcerative colitis compared with controls. METHODS: Gastroscopy with duodenal biopsies and/or colonoscopy with biopsies were conducted in 42 patients with AS treated or not treated with nonsteroidal antiinflammatory drugs (NSAID), in 15 with ulcerative colitis, and in 46 controls. Lymphocytic infiltration in the lamina propria and intraepithelial infiltration were quantified by histological score. iNOS expression was assessed by immunohistochemistry with monoclonal antibodies, and iNOS activity was determined by radiochemical assay. RESULTS: Endoscopic examination of the gastroduodenal or colonic mucosa did not reveal macroscopic lesions in the AS patients. In the duodenum, mucosal lymphocytic infiltration was found in 83.3% of the AS group compared to 48.6% of controls (p = 0.02), and was independent of the NSAID intake. Intraepithelial lymphocyte infiltration was increased in both duodenum and colon in AS patients compared to controls. iNOS activity in duodenum and colon and expression of iNOS protein in lamina propria inflammatory cells was increased in AS patients compared to controls. CONCLUSION: Lymphocytic infiltration and iNOS expression and activity were detected in duodenal and colonic mucosa from patients with AS. Such findings may indicate an inflammatory process in the small intestine and colon of patients with AS. |
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Authors:
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Dominique Lamarque; Jeanne Tran Van Nhieu; Maxime Breban; Christophe Bernardeau; Nadine Martin-Garcia; Zoltan Szepes; Jean-Charles Delchier; Brendan Whittle; Pascal Claudepierre |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of rheumatology Volume: 30 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-12-16 Completed Date: 2004-01-05 Revised Date: 2011-10-27 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 2428-36 Citation Subset: IM |
Affiliation:
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Institut National de la Santé et de la Recherche Médicale (INSERM) U99, Department of Gastroenterology, AP-HP Hôpital Henri Mondor, F-94010 Créteil, France. dominique.lamarque@bch.ap-hop-paris.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents, Non-Steroidal / therapeutic use Case-Control Studies Cell Movement Colon / enzymology, metabolism, microbiology, pathology Duodenum / enzymology, metabolism, microbiology, pathology Gastroscopy Helicobacter pylori / isolation & purification Humans Immunohistochemistry Interferon-gamma / metabolism Interleukin-10 / metabolism Interleukin-2 / metabolism Intestinal Mucosa / enzymology*, metabolism, microbiology, pathology* Lymphocytes / pathology*, physiology Middle Aged Nitric Oxide Synthase / metabolism* Nitric Oxide Synthase Type II Spondylitis, Ankylosing / enzymology*, metabolism, microbiology, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Interleukin-2; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma; EC 1.14.13.39/NOS2 protein, human; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type II |
| Comments/Corrections | |
Comment In:
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J Rheumatol. 2003 Nov;30(11):2306-7
[PMID:
14677167
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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