Document Detail

Lymphocytic hypophysitis in the pediatric population.
MedLine Citation:
PMID:  18299851     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Lymphocytic hypophysitis (LYH) is a rare inflammatory disease of the pituitary gland that usually affects women in their ante- or immediate postpartum period; males are affected less frequently than females. An autoimmune pathogenesis is suggested. Symptoms comprise anterior and/or posterior pituitary insufficiency of varying degrees. So far, specific characteristics of this rare disease in childhood are not well described. CASE HISTORY: We report the case of a 12-year-and-11-month-old boy with histologically confirmed LYH clinically presenting with diabetes insipidus. A high-dose steroid therapy was administered, in which the therapeutic effect was uncertain. His 6-year follow-up is presented. DISCUSSION: The literature is reviewed for children presenting with LYH; their characteristics, pituitary involvement, and clinical follow-up are listed and discussed. CONCLUSION: Even though magnetic resonance imaging can be highly suspicious for LYH, only surgical exploration can confirm the diagnosis. The efficacy of medical treatment is still controversial; a close follow-up is necessary to control and correct the endocrinological function, if required.
Verena Gellner; Senta Kurschel; Michael Scarpatetti; Michael Mokry
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2008-02-26
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  24     ISSN:  0256-7040     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-05-28     Completed Date:  2009-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  785-92     Citation Subset:  IM    
Department of Neurosurgery, Medical University, Auenbruggerplatz 29, 8036, Graz, Austria.
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MeSH Terms
Diabetes Insipidus / complications
Follow-Up Studies
Lymphocytosis / complications*,  diagnosis,  epidemiology*,  pathology
Magnetic Resonance Imaging
Pituitary Diseases / complications*,  diagnosis,  epidemiology*,  pathology

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