Document Detail

Lymphocytic hypophysitis in a patient presenting with sequential episodes of optic neuritis.
MedLine Citation:
PMID:  20676777     Owner:  NLM     Status:  In-Data-Review    
A 41-year-old man presented with left optic neuritis (ON) without evidence of other autoimmune disease or hormonal imbalance. MRI showed enlargement of the left optic nerve but no sellar lesion. The patient recovered after steroid therapy but later developed right ON and required treatment again. Follow-up MRI revealed an ill-defined, enlarging sellar lesion with enhancement extending into the right cavernous sinus, and the patient developed symptoms of fatigue and loss of libido. Hormonal studies revealed hypogonadism and hypocortisolism. All laboratory investigation for autoimmune and infectious diseases remained negative. A transsphenoidal biopsy of the lesion revealed lymphocytic hypophysitis. The concomitant development of lymphocytic hypophysitis and optic neuritis suggests a common and likely autoimmune etiology. Visual loss in patients with LYH can sometimes be due to ON rather than compression of the optic apparatus, with significant implications for treatment strategies.
Garrett K Zoeller; Ronald J Benveniste; F A Farhadi; Jocelyn H Bruce
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pituitary     Volume:  15     ISSN:  1573-7403     ISO Abbreviation:  Pituitary     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814578     Medline TA:  Pituitary     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-5     Citation Subset:  IM    
Department of Neurological Surgery, University of Miami Miller School of Medicine, Lois Pope LIFE Center, 1095 NW 14th Terrace (D4-6), Miami, FL, 33136, USA.
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