Document Detail


Lymphocytic gastritis in Helicobacter pylori-positive gastric MALT lymphoma--report of two cases.
MedLine Citation:
PMID:  15908769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both lymphocytic gastritis and gastric mucosa associated lymphoid tissue (MALT) lymphoma are associated with Helicobacter pylori (H. pylori) infection. However, this association has not been fully elucidated. We report two cases of lymphocytic gastritis in 57-year-old male and 47-year-old female patients which were diagnosed after the H. pylori eradication to treat gastric MALT lymphoma. MALT lymphoma was successfully treated in case 1, but residual MALT lymphoma remained in case 2. During the follow-up endoscopic examinations, several elevated erosions in case 1 and irregular mucosal atrophy in case 2 were newly detected. Biopsy specimens showed marked infiltration of lymphocytes in the surface epithelium (56.6+/-15.9 intraepithelial lymphocytes (IELs)/100 epithelial cells in case 1 and 40.5+/-9.3 IELs/100 epithelial cells in case 2), which were exclusively CD8-positive T lymphocytes. These findings suggest that H. pylori infection may cause a monoclonal proliferation of B lymphocytes, leading to MALT lymphoma as well as polyclonal proliferation of T lymphocytes which subsequently infiltrated into the surface epithelium as a host immune reaction, resulting in lymphocytic gastritis.
Authors:
Dong Eun Song; Jung Sun Kim; Joo Ryung Huh; Jene Choi; Se Jin Jang; Eunsil Yu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi     Volume:  45     ISSN:  1598-9992     ISO Abbreviation:  Korean J Gastroenterol     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-23     Completed Date:  2006-09-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101189416     Medline TA:  Korean J Gastroenterol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  354-60     Citation Subset:  IM    
Affiliation:
Department of Pathology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Gastric Mucosa / pathology*
Gastritis / complications*,  microbiology,  pathology
Helicobacter Infections / complications*
Helicobacter pylori*
Humans
Lymphocytes / pathology*
Lymphoma, B-Cell, Marginal Zone / complications*,  microbiology
Male
Middle Aged
Stomach Neoplasms / complications*

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