Document Detail

Lymphocytic angiitis following streptokinase therapy.
MedLine Citation:
PMID:  3060319     Owner:  NLM     Status:  MEDLINE    
A palpable, purpuric, nonpruritic eruption occurred in a 64-year-old man nine days after he received intravenous streptokinase therapy, which was successful in treating acute myocardial infarction. Perivascular mononuclear and eosinophilic infiltration was noted on routine staining of skin biopsy specimens: immune complexes, fibrin, and complement deposition in the skin microvasculature were demonstrated on immunofluorescent studies. These findings confirm the diagnosis of lymphocytic angiitis induced by streptokinase. Intermediate-type hypersensitivity reactions to streptokinase apparently have variable levels of severity. Clinicians who use streptokinase as a therapeutic agent should be aware of this potentially serious complication.
W A Sorber; V Herbst
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cutis     Volume:  42     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1989-02-03     Completed Date:  1989-02-03     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-8     Citation Subset:  IM    
Muncy Valley Hospital, Pennsylvania.
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MeSH Terms
Fluorescent Antibody Technique
Lymphocytes / pathology
Middle Aged
Streptokinase / adverse effects*
Vasculitis, Leukocytoclastic, Cutaneous / chemically induced*,  immunology,  pathology
Reg. No./Substance:
EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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