Document Detail

Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis.
MedLine Citation:
PMID:  9152609     Owner:  NLM     Status:  MEDLINE    
One hundred and twenty-four cases of lymphocytic adenohypophysitis have been reported since 1962. Nearly 60% of the cases in women involved inset of the disease in relation to pregnancy. Headache and visual field defects were the most frequent symptoms. Most patients showed signs of either isolated or multiple anterior pituitary hormone deficiency. ACTH secretion was impaired the most frequently, followed by TSH, gonadotropins, GH and PRL secretion. One third of the cases involved hyperprolactinemia. Tissue from patients with lymphocytic infundibuloneurohypophysitis, also suffering from DI, revealed lymphocytic inflammation limited to the infundibulum, stalk, and neurohypophysis. Twenty of these 124 lymphocytic adenohypophysitis patients developed DI before treatment, and neuroimaging studies revealed thickening of the pituitary stalk in some. At least in a few cases, chronic lymphocytic infiltration occurred in both the infundibuloneurohypophysitis and adenohypophysis. Although both lymphocytic adenohypophysitis and infundibuloneurohypophysitis may be caused by autoimmune disorders, the antigens involved may differ.
K Hashimoto; T Takao; S Makino
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Endocrine journal     Volume:  44     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-08-20     Completed Date:  1997-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Second Department of Internal Medicine, Kochi Medical School, Japan.
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MeSH Terms
Lymphocytes / pathology*
Lymphocytosis* / complications,  etiology,  physiopathology
Middle Aged
Pituitary Diseases* / complications,  etiology,  physiopathology
Pituitary Gland, Anterior
Pituitary Gland, Posterior
Pituitary Hormones, Anterior / deficiency
Pregnancy Complications* / etiology,  physiopathology,  therapy
Reg. No./Substance:
0/Pituitary Hormones, Anterior

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