| Lymphocyte transformation in lung cancer patients. | |
| | |
MedLine Citation:
|
PMID: 838757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lymphocyte mitogen transformation has been studied before and after treatment with sugery and radiation in lung cancer patients, in surgically treated patients with non-malignant lesions, and in healthy persons. We have shown a fall in lymphocyte response following operation, even in patients with benign lesions. Patients with cancer have a lymphocyte response which is depressed following operation more than the patients with benign lesions. Following cobalt irradiation there is a further fall in response. We were not able to identify a factor in the serum of patient with depressed lymphocyte transfromation which affected lymphocyte response to Phytohemagglutinin. A recovery in response towards pre-treatment levels occurs earliest in patients with benign lesions. In the patients who had not received irradiation, lymphocyte transformation did not have any prognostic value. In patients with advancing cancer, who ultimately die following irradiation, there is no recovery of response. This lack of recovery signals a very poor prognosis. |
| | |
Authors:
|
P Coy; J W Thomas; N Hasham |
Related Documents
:
|
7694117 - Chromosomal radiosensitivity in common variable immune deficiency. 53997 - Phosphorylase activity in chronic erythremic myelosis. 15464637 - Lymphocyte subsets in bell's palsy: immune pathogenesis and outcome prediction. 19145677 - Detection of zap-70 in patients with chronic lymphocytic leukemia. 19784427 - Benign paroxysmal positional vertigo recurrence and persistence. 20463187 - High disease activity is a predictor of cortical hand bone loss in post-menopausal pati... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the Canadian Association of Radiologists Volume: 28 ISSN: 0008-2902 ISO Abbreviation: J Can Assoc Radiol Publication Date: 1977 Mar |
Date Detail:
|
Created Date: 1977-04-30 Completed Date: 1977-04-30 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7505589 Medline TA: J Can Assoc Radiol Country: CANADA |
Other Details:
|
Languages: eng Pagination: 43-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Concanavalin A
/
pharmacology Humans Lectins / pharmacology Lung Neoplasms / immunology*, radiotherapy, surgery Lymphocyte Activation* / drug effects, radiation effects Lymphocytes / drug effects, radiation effects |
| Chemical | |
Reg. No./Substance:
|
0/Lectins; 11028-71-0/Concanavalin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ureteropelvic junction obstruction in the adult.
Next Document: Telephone line transmission of rectilinear radionuclide scans. Report of a pilot project.