Document Detail


Lymphocyte subset reconstitution in pediatric liver recipients induced with steroid-free rabbit anti-human thymocyte globulin.
MedLine Citation:
PMID:  18972618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple measurements of lymphocyte subsets in 91 children treated with steroid-free tacrolimus, and rabbit anti-human thymocyte globulin induction demonstrate early reconstitution of T-cytotoxic cells, and gradual reconstitution of all other subsets, which is complete after one yr. Rejection-prone children demonstrate significantly higher counts of lymphocytes and all subsets prior to liver transplantation, and may exemplify one basis for enhanced baseline immunocompetence.
Authors:
Anjan Talukdar; Chethan AshokKumar; Jennifer Farrar; Patrick Wilson; Arun Janakiramanan; Mary Tregaskes; Rakesh Sindhi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric transplantation     Volume:  12     ISSN:  1399-3046     ISO Abbreviation:  Pediatr Transplant     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-29     Completed Date:  2009-03-26     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  9802574     Medline TA:  Pediatr Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  804-8     Citation Subset:  IM    
Affiliation:
Pediatric Transplantation Laboratory, Hillman Center for Pediatric Transplantation, Childrens Hospital of Pgh and the University of Pittsburgh, Pittsburgh, PA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Antilymphocyte Serum / metabolism*
Child
Child, Preschool
Female
Humans
Infant
Liver Diseases / blood*,  therapy*
Liver Transplantation / methods*
Lymphocyte Subsets / cytology*
Male
Rabbits
Steroids / metabolism*
T-Lymphocytes, Cytotoxic / metabolism
Tacrolimus / administration & dosage
Grant Support
ID/Acronym/Agency:
5R01AI49156-05/AI/NIAID NIH HHS; R01 AI049156-01A1/AI/NIAID NIH HHS; R01 AI073895-01/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antilymphocyte Serum; 0/Steroids; 109581-93-3/Tacrolimus
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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