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Lymphocyte subset characterization in patients with early clinical presentation of coronary heart disease.
MedLine Citation:
PMID:  22903683     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study aimed to investigate lymphocyte populations in non-diabetic patients with early clinical presentation of coronary heart disease (CHD). Twenty-five consecutive middle-aged (<55 years) out-patients with CHD (acute myocardial infarction in the previous 3 months) and stable clinical conditions (>1 month) underwent venous blood sampling in order to determinate CD3(+) (T-lymphocytes), CD19(+) (B-lymphocytes), CD4(+) (helper/inducer lymphocytes) and CD8(+) (suppressor/cytotoxic lymphocytes) populations. Patients with diabetes, heart failure symptoms, recent revascularization (<30 days) were excluded. Twenty-five patients matched for age, gender and risk factors were enrolled as controls. All patients with CHD previously underwent coronary angiography. CHD patients showed lower CD3(+) levels (70.96 ± 4.72 vs. 74.12 ± 4.93 %, p < 0.05) and CD8(+) (37.80 ± 7.15 vs. 46.36 ± 5.22 %, p < 0.001) but higher CD4(+) (37.32 ± 7.99 vs. 31.64 ± 4.72 %, p < 0.01) and CD4(+)/CD8(+) ratio (1.06 ± 0.43 vs. 0.69 ± 0.13, p < 0.001). Difference in CD19(+) levels was not statistically significant. Subjects with an impaired (≤55 %) left ventricular ejection fraction were characterized by lower levels of CD8(+) (33.23 ± 7.04 vs. 43.76 ± 7.40 %, p < 0.05) and higher levels of CD4(+) (38.31 ± 8.23 vs. 32.73 ± 6.08 %, p < 0.05) and CD4(+)/CD8(+) ratio (1.06 ± 0.38 vs. 0.79 ± 0.34, p < 0.05). CD8(+) levels inversely related to severity of coronary atherosclerosis (r = -0.37, p < 0.01). In conclusion, subjects with early clinical presentation of CHD are characterized by an altered CD4(+)/CD8(+) ratio and lower CD3(+) levels.
Authors:
Natale Daniele Brunetti; Carmine D'Antuono; Michele Rana; Girolamo D'Arienzo; Luisa De Gennaro; Matteo Di Biase
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-18
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  -     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Cardiology Department, University of Foggia, Viale Pinto 1, 71100, Foggia, Italy, nd.brunetti@unifg.it.
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