Document Detail


Lymphocyte subpopulations in long-term dialysis patients: a case-controlled study of the effects of blood transfusion.
MedLine Citation:
PMID:  2402779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymphocyte subsets in a group of intensely transfused (greater than 10 units/year) patients on long-term hemodialysis were compared with those in a carefully controlled population of lightly transfused (1-10 units/year, no units during study period) long-term dialysis patients. The data confirm previous reports of lymphopenia and a symmetrical reduction of both T- and B-cell subpopulations in patients on long-term dialysis. Eleven (36.7%) of 30 intensely transfused dialysis (ITD) patients had a low T8 population when expressed as a percentage value, while 0 of 25 lightly transfused dialysis (LTD) control patients exhibited a low percentage of T8 cells. There were no significant absolute differences between the lymphocyte subsets in the ITD and LTD patients. These data contrast with previous reports of other groups of ITD patients in whom there was an observed increase in T8 cytotoxic suppressor cells. Our findings suggest that the immunologic effects of renal failure and long-term dialysis largely override the increase in T8 lymphocyte subsets observed in other groups of transfused patients. There is little difference between ITD and LTD patients, but both groups are significantly different from nontransfused controls. Further longitudinal studies are needed in completely untransfused patients to resolve the contribution of minimal transfusion therapy to the immunologic deficits observed in long-term dialysis patients.
Authors:
J P Crowley; C R Valeri; J B Metzger; L Pono; J A Chazan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Transfusion     Volume:  30     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-24     Completed Date:  1990-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  644-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Brown University, Providence, Rhode Island.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Transfusion / adverse effects
Case-Control Studies
Female
Humans
Kidney Diseases / blood,  epidemiology,  therapy
Lymphocytes / cytology*,  immunology
Male
Middle Aged
Phenotype
Renal Dialysis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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