Document Detail

Lymphocyte reactivity to Crohn's ileal homogenates.
MedLine Citation:
PMID:  7154058     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to demonstrate whether lymphocytes derived from patients with Crohn's disease and their household contacts would demonstrate increased reactivity upon exposure to tissue homogenates prepared from the terminal ileum of patients with Crohn's disease. It was demonstrated that 4 of 18 patients, 9 of 30 household contacts, and 0 of 13 control subjects exhibited statistically greater lymphocyte thymidine incorporation in response to Crohn's tissue homogenates (contacts vs control, P = 0.025) [Fisher Exact Test (FET)]. However, homogenates prepared from the terminal ileum of control subjects without inflammatory bowel disease also induced lymphocyte reactivity in 1 patient, 5 contacts, and 1 control subject. Factors may be present in homogenates prepared from human terminal ileum which induce lymphocyte reactivity in some patients with Crohn's disease and household contacts.
J V Weinstock; M R Simon
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical & laboratory immunology     Volume:  9     ISSN:  0141-2760     ISO Abbreviation:  J Clin Lab Immunol     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  7808987     Medline TA:  J Clin Lab Immunol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Crohn Disease / immunology*,  transmission
Ileum / immunology
Lymphocyte Activation
Lymphocytes / immunology*
Middle Aged
Grant Support

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