| Lymphocyte proliferation and nucleoid sedimentation in a case of premature aging distinct from Werner's syndrome. | |
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MedLine Citation:
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PMID: 3740938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphocyte proliferation and nucleoid sedimentation were studied in a patient with premature aging resembling the Werner's syndrome (WS). Onset of patchy brown hyperpigmentations at the age of 9 months permitted distinction from classical WS and suggested a WS-like premature aging disease. By photometric recording of density changes during cell culture, we examined the course of cell proliferation after PHA stimulation over 7 days and compared these results to those obtained in two normal controls. Cultured cells of the patient displayed an aberrant proliferation pattern characterized by continuous growth without an initial reduction phase. The markedly reduced proliferative capacity of purified cells from the patient could in part be corrected by fetal bovine serum. The cells of the patient displayed a characteristic nucleoid sedimentation profile after ultraviolet irradiation indicating retarded DNA replication, which may be a common feature of various premature aging diseases. The absence of thermolability of cell proliferation and the presence of a high number of chromatid aberrations disclosed differences from classical WS. |
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Authors:
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M A Kim; R Happle; H Traupe |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
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Title: Archives of dermatological research Volume: 278 ISSN: 0340-3696 ISO Abbreviation: Arch. Dermatol. Res. Publication Date: 1986 |
Date Detail:
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Created Date: 1986-09-25 Completed Date: 1986-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000462 Medline TA: Arch Dermatol Res Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 277-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Division Cells, Cultured Chromosome Aberrations DNA Replication* Diagnosis, Differential Humans Lymphocyte Activation* Male Middle Aged Progeria / diagnosis*, genetics, immunology Skin Pigmentation Ultraviolet Rays Werner Syndrome / diagnosis*, genetics, immunology |
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