Document Detail

Lymphocyte immunotherapy (LI) increases serum levels of progesterone induced blocking factor (PIBF).
MedLine Citation:
PMID:  9138449     Owner:  NLM     Status:  MEDLINE    
PROBLEM: To determine if allogenic stimulation from leukocyte immunization (LI) can increase the production of an immunomodulatory protein called progesterone induced blocking factor (PIBF) by CD8+ T-lymphocytes. METHODS: The study group consisted of 35 women, 29 who failed to conceive after repeated embryo transfers (ETs) and six with recurrent spontaneous abortion (RSA). The women underwent LI using the the male partner's blood as the source of leukocytes. Progesterone induced blocking factor was measured pre- and post-LI with an immunocytochemistry method using a PIBF-specific polyclonal antibody. RESULTS: The mean percentage of lymphocytes expressing PIBF, as well as the percentage of cases of whose PIBF level increased to 1% or more, was significantly higher post-LI, Similarly post-LI, there was a significantly lower percentage of zero PIBF levels. CONCLUSIONS: Leukocyte immunization causes an increase in PIBF in many cases. Possibly the improved pregnancy outcome in immunized patients with RSA or previous failure to conceive with in vitro fertilization may be partially or possibly completely explained by its stimulatory effect on PIBF.
J H Check; M Arwitz; J Gross; M Peymer; J Szekeres-Bartho
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  37     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-08     Completed Date:  1997-05-08     Revised Date:  2008-05-06    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  IM; X    
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.
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MeSH Terms
Abortion, Habitual / immunology
Adoptive Transfer*
CD8-Positive T-Lymphocytes / metabolism,  transplantation
Embryo Transfer / adverse effects
Fertilization in Vitro / adverse effects
Isoantigens / immunology
Pregnancy Proteins / biosynthesis*,  blood*
Progesterone / pharmacology*
Protein Binding / drug effects
Suppressor Factors, Immunologic / biosynthesis*,  blood*
Reg. No./Substance:
0/Isoantigens; 0/PIBF1 protein, human; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic; 57-83-0/Progesterone

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