Document Detail

Lymphocyte function and cytokine production during incremental exercise in active and sedentary males and females.
MedLine Citation:
PMID:  8973979     Owner:  NLM     Status:  MEDLINE    
This study examined the effects of acute continuous incremental exercise on lymphocyte mitogenic function and cytokine production in physically active and sedentary males and females. Physically active (n = 32) and sedentary (N = 32) male and female subjects were randomly assigned to an exercise or control condition. Exercise involved a continuous incremental protocol consisting of cycling for 3 periods of 6 min at workrates corresponding to 55%, 70% and 85% VO2peak. Blood samples were drawn from a venous catheter at baseline, 6 min, 12 min and 18 min, and 2 h following completion of exercise. Relative to baseline and control condition the percentage of T (CD3+) and B cells (CD19+) significantly decreased, and the percentage of NK cells (CD3-CD16+CD56+) increased (p < 0.001) during each stage of the incremental exercise test. The proliferative response to ConA was suppressed, enhanced, or unchanged using 1.25 micrograms/ml, 2.5 micrograms/ml and 5.0 micrograms/ml ConA, respectively. The in-vitro production of IL-1 and IFN-gamma increased during each workload. In contrast IL-4 production did not change during exercise. The resting and exercise induced alterations in lymphocyte function and cytokine production were independent of gender and fitness level, and returned to baseline 2 h into recovery. The in-vitro production of IFN-gamma and IL-4 suggests that physical activity may alter the balance of TH1 and TH2 lymphocytes.
N M Moyna; G R Acker; J R Fulton; K Weber; F L Goss; R J Robertson; D J Tollerud; B S Rabin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of sports medicine     Volume:  17     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-19     Completed Date:  1997-03-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  585-91     Citation Subset:  IM    
Brain, Behavior and Immunity Center, University of Pittsburgh Medical Center, PA, USA.
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MeSH Terms
Analysis of Variance
Cell Division / drug effects
Cytokines / biosynthesis*
Exercise / physiology*
Lymphocytes / cytology*
Mitogens / pharmacology
Plant Proteins / pharmacology
Sex Factors
Grant Support
Reg. No./Substance:
0/Cytokines; 0/Mitogens; 0/Plant Proteins; 0/canavalin protein, Canavalia ensiformis

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