| Lymphocyte function and cytokine production during incremental exercise in active and sedentary males and females. | |
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MedLine Citation:
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PMID: 8973979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the effects of acute continuous incremental exercise on lymphocyte mitogenic function and cytokine production in physically active and sedentary males and females. Physically active (n = 32) and sedentary (N = 32) male and female subjects were randomly assigned to an exercise or control condition. Exercise involved a continuous incremental protocol consisting of cycling for 3 periods of 6 min at workrates corresponding to 55%, 70% and 85% VO2peak. Blood samples were drawn from a venous catheter at baseline, 6 min, 12 min and 18 min, and 2 h following completion of exercise. Relative to baseline and control condition the percentage of T (CD3+) and B cells (CD19+) significantly decreased, and the percentage of NK cells (CD3-CD16+CD56+) increased (p < 0.001) during each stage of the incremental exercise test. The proliferative response to ConA was suppressed, enhanced, or unchanged using 1.25 micrograms/ml, 2.5 micrograms/ml and 5.0 micrograms/ml ConA, respectively. The in-vitro production of IL-1 and IFN-gamma increased during each workload. In contrast IL-4 production did not change during exercise. The resting and exercise induced alterations in lymphocyte function and cytokine production were independent of gender and fitness level, and returned to baseline 2 h into recovery. The in-vitro production of IFN-gamma and IL-4 suggests that physical activity may alter the balance of TH1 and TH2 lymphocytes. |
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Authors:
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N M Moyna; G R Acker; J R Fulton; K Weber; F L Goss; R J Robertson; D J Tollerud; B S Rabin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of sports medicine Volume: 17 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-03-19 Completed Date: 1997-03-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 585-91 Citation Subset: IM |
Affiliation:
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Brain, Behavior and Immunity Center, University of Pittsburgh Medical Center, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Cell Division / drug effects Cytokines / biosynthesis* Exercise / physiology* Female Humans Lymphocytes / cytology* Male Mitogens / pharmacology Plant Proteins / pharmacology Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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MH43411/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Mitogens; 0/Plant Proteins; 0/canavalin protein, Canavalia ensiformis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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