Document Detail

Lymphocyte differentiation in the rabbit thymus.
MedLine Citation:
PMID:  1008533     Owner:  NLM     Status:  MEDLINE    
Density separation of rabbit thymus lymphoid cells on a continuous and linear Ficoll-Metrizoate gradient resulted in the appearance of three subpopulations of lymphoid cells with peak fractions at densities of approx. 1.067, 1.077 and 1.084 g/ml. The subpopulation of the lowest density appeared to consist of cortisone-resistant cells of various size classes, all characterized by a relative low nucleo-cytoplasmic ratio. Glycerol-induced redistribution of particles within the plasma membrane (IMP) of the lymphoid cells, as revealed with the freeze-fracture technique, was present in the subpopulation of lowest density as well as in thymus lymphoid cells of cortisone-treated rabbits in a high percentage of the cells, and present in a very small percentage of the cells of highest density. It is concluded that an increase in the mobility of plasma membrane components may be a significant feature of T-cell education in the rabbit thymus.
W Leene; P J Roholl; C de Groot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annales d'immunologie     Volume:  127     ISSN:  0300-4910     ISO Abbreviation:  Ann. Immunol. (Paris)     Publication Date:    1976 Nov-Dec
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0353045     Medline TA:  Ann Immunol (Paris)     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  911-21     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation
Cell Membrane / ultrastructure
Cell Nucleus / ultrastructure
Cell Separation
Freeze Fracturing
Glycerol / pharmacology
Hydrocortisone / pharmacology*
Lymphocytes / cytology*,  ultrastructure
Microscopy, Electron
Microscopy, Electron, Scanning
Thymus Gland / cytology*
Reg. No./Substance:
50-23-7/Hydrocortisone; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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