Document Detail


Lymphocyte cell subpopulations during acute post-streptococcal glomerulonephritis: cell surface antigens and binding of streptococcal membrane antigens and C-reactive protein.
MedLine Citation:
PMID:  7039887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T lymphocyte surface markers were examined in 23 patients with acute post-streptococcal glomerulonephritis (AGN) in parallel with normal controls and individuals without nephritis who showed evidence of pharyngeal or skin-sore beta-haemolytic streptococcal infection. Numbers of T gamma cells were similar in AGN and normal controls but were significantly lower (P less than 0.05) than those in skin-sore culture-positive streptococcal infection controls. Numbers of T mu cells were similar in AGN and normal controls but were lower (P less than 0.05) than those observed in streptococcal controls. Percentages of T mu cells were similar in AGN and normal controls but were lower (P less than 0.05) than those recorded in streptococcal infection control groups. Proportions of T cells were reduced during AGN (P less than 0.05). Lymphocytes capable of binding type 12 group A streptococcal membranes were increased (30.4%) in patients with AGN as compared to normal controls (4.1%). Subjects with streptococcal infection alone showed elevated but intermediate relative numbers (10.5%) of lymphocytes binding group A membranes. Increased relative numbers of both B and T lymphocytes binding group A streptococcal membranes were present in both AGN and non-nephritogenic streptococcal infection controls.
Authors:
R C Williams; I Van de Rijn; H Reid; T Poon-King; J B Zabriskie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  46     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  397-405     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Antigens, Bacterial / immunology
Antigens, Surface / immunology*
B-Lymphocytes / immunology
C-Reactive Protein / immunology*
Child
Child, Preschool
Glomerulonephritis / immunology*
Humans
Leukocyte Count
Streptococcal Infections / immunology*
Streptococcus pyogenes / immunology
T-Lymphocytes / classification*,  immunology
Grant Support
ID/Acronym/Agency:
AM 136900/AM/NIADDK NIH HHS; AMAI 13824/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Antigens, Surface; 9007-41-4/C-Reactive Protein
Comments/Corrections

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