Document Detail

Lymphocyte blastogenesis in patients receiving hemodialysis.
MedLine Citation:
PMID:  1275624     Owner:  NLM     Status:  MEDLINE    
Lymphocyte blastogenic transformation in response to plant lectins and allogenic cells was studied in patients with nonuremic, far-advanced, chronic renal failure and in healthy controls. Cell cultures were studied in the presence of normal sera, patient's sera, and with media of different buffering capacities. Minimal blastogenic depression was observed when patient's lymphocytes were cultured in indifferent plasma with effective bicarbonate buffering compared with the use of pooled patient's plasma or HEPES buffer. Fresh plasma in culture depressed concanavalin A (Con A) blastogenesis. The data suggest that, under optimal conditions, lymphocytes from patients with chronic severe renal insufficiency are more responsive to stimuli than previously reported and as a group are near normal control values. Further, the defect observed may be a result of intracellular acidosis.
M L Webel; R E Ritts; W A Briggs; J A Light
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  136     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  682-7     Citation Subset:  AIM; IM    
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MeSH Terms
Concanavalin A / pharmacology
Kidney Failure, Chronic / blood,  immunology*
Lectins / pharmacology
Lymphocyte Activation*
Mitogens / pharmacology
Renal Dialysis*
Reg. No./Substance:
0/Lectins; 0/Mitogens; 11028-71-0/Concanavalin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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