Document Detail

Lymphocyte abnormalities predicting a poor prognosis in Hodgkin's disease. A long-term follow-up.
MedLine Citation:
PMID:  1855177     Owner:  NLM     Status:  MEDLINE    
Two hundred sixty-two adult patients with Hodgkin's disease (HD) were studied. Incorporation of carbon-14-thymidine was measured in unstimulated monocyte-depleted lymphocyte cultures, and in cultures activated by concanavalin A (Con-A) before institution of therapy in all patients. Total blood lymphocytes and T-cell subsets were enumerated in the last 108 patients. Patients had significantly decreased total (CD3+, CD4+, CD8+) and relative (CD3+, CD4+) T-cell counts compared with healthy controls. Stage IV patients tended to have lower total lymphocyte and subset counts than remaining patients. However, significantly reduced total lymphocyte and CD8+ counts were only observed in comparison to patients in clinical stage II. Thirty-three percent of patients had an increased spontaneous and a decreased Con-A-induced blood lymphocyte DNA synthesis. Functional lymphocyte abnormalities were related to advanced clinical stage, high age, mixed cellularity, and lymphocyte depletion histopathology and presence of B symptoms. The 10-year survival of patients in this group was 36%, compared with 62% for the remainder. In a multivariate analysis of the whole series lymphocyte DNA synthesis was besides age the strongest predictor of prognosis. In univariate analyses of the second patient series total lymphocyte, T-cell and subset counts were related to prognosis. These relatively simple lymphocyte functional tests may help to identify young HD patients for whom intensive cytoreductive therapy with or without autologous stem cell support may be the best therapeutic option.
O Tullgren; G Grimfors; G Holm; B Johansson; E Svedmyr; C Wedelin; H Mellstedt; K Merk; M Björkholm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer     Volume:  68     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-28     Completed Date:  1991-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  768-75     Citation Subset:  AIM; IM    
Department of Medicine, Karolinska Hospital and Institute, Stockholm, Sweden.
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MeSH Terms
Actuarial Analysis
Aged, 80 and over
DNA / biosynthesis,  blood
Fluorescent Antibody Technique
Follow-Up Studies
Hodgkin Disease / blood*,  mortality*
Leukocyte Count
Middle Aged
Statistics as Topic
T-Lymphocyte Subsets / metabolism,  physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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