Document Detail


Lymphocytapheresis in chronic progressive multiple sclerosis: immunologic and clinical effects.
MedLine Citation:
PMID:  6539868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effects of lymphocytapheresis in five patients with chronic progressive MS. Ten lymphocytapheresis treatments were given in 2 weeks, followed by 1 treatment every 2 weeks for 2 to 6 months. Four of five patients had a fall in the circulating lymphocyte count during the initial treatment, and in three patients a modest lymphopenia was sustained with maintenance therapy. In patients with abnormal T4:T8 ratios, no improvement in the T4:T8 ratio occurred. There was no apparent clinical effect in this pilot study.
Authors:
S L Hauser; M Fosburg; S V Kevy; H L Weiner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  34     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-07-30     Completed Date:  1984-07-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  922-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Immunosuppression
Lymphocytes / immunology*
Male
Middle Aged
Multiple Sclerosis / immunology*,  therapy
Plasmapheresis*
Grant Support
ID/Acronym/Agency:
NS-17182/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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