Document Detail

Lympho-epithelial interactions in rat thymus during pregnancy.
MedLine Citation:
PMID:  12056632     Owner:  NLM     Status:  MEDLINE    
Alterations in the thymic epithelial cell activity were analysed during pregnancy and lactation in Wistar rats by examining the presence and in situ distribution of lymphoepithelial complexes formed by thymic nurse cells (TNC). TNC were identified in paraffin sections by their expression of MHC class II antigens, CD54 molecule and a neuromarker, protein gene product 9.5 (PGP9.5). On the first days of pregnancy (gestational days, GD) the number of PGP9.5+ TNC was found to decrease abruptly. On GD 14, a transient increase was noted in the number of PGP9.5+, MHC+, CD54+ TNC. Another increase was observed in the course of lactation, when the weight of the thymus reached the lowest values. While the increase in TNC numbers during lactation may be linked to the process of reconstruction of the thymic lymphoid population, the augmented activity of lymphoepithelial interactions on GD14 may be associated with thymic engagement in pregnancy-induced immune processes.
R Brelińska; A Paczkowska; K Kowalska; J Jaroszewski
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  40     ISSN:  0239-8508     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2002  
Date Detail:
Created Date:  2002-06-11     Completed Date:  2003-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  175-6     Citation Subset:  IM    
Department of Histology and Embryology, University of Medical Sciences, Poznań, Poland.
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MeSH Terms
Epithelial Cells / physiology*
Genes, MHC Class II / genetics
Intercellular Adhesion Molecule-1 / metabolism
Lactation / physiology
Lymphatic System / physiology*
Pregnancy, Animal / physiology*
Rats, Wistar
Thiolester Hydrolases / metabolism
Thymus Gland / cytology*,  physiology
Ubiquitin Thiolesterase
Reg. No./Substance:
126547-89-5/Intercellular Adhesion Molecule-1; EC 3.1.2.-/Thiolester Hydrolases; EC Thiolesterase

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