Document Detail

Lymphatics and lymph in acute lung injury.
MedLine Citation:
PMID:  18195623     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Lymph flow will be discussed as part of the drainage and fluid balance of lung tissue and abdomen as well as a qualitative analysis of inflammatory processes. RECENT FINDINGS: Measurement of lung lymph is still a technical challenge. Mechanical ventilation and positive end-expiratory pressure impede lung lymph flow by increased intrathoracic pressure and increased central venous pressure. Positive end-expiratory pressure may thus enhance edema formation of the lung. Inflammatory spread from abdomen to the lung via the lymphatic system has been shown in a number of experimental studies. Ligation or diversion of the thoracic duct has been proposed to blunt the effects of noxious stimuli mediated by lymphatics to the lungs. Lymphatics have a major role on abdominal fluid balance while draining extravascular fluid accumulation and edema, especially during sepsis. Mechanical ventilation with high airway pressure increases abdominal edema (ascites) and spontaneous breathing protects from edema formation. SUMMARY: Lymph flow measurements are still a difficult task to perform; however, new results show an important function in the fluid balance of the lung and abdomen. Inflammatory spread may occur from the lung to the periphery by the blood stream and from the abdomen to the lung by lymph flow.
Göran Hedenstierna; Marco Lattuada
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in critical care     Volume:  14     ISSN:  1070-5295     ISO Abbreviation:  Curr Opin Crit Care     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-15     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504454     Medline TA:  Curr Opin Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Department of Medical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden.
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MeSH Terms
Abdominal Cavity / physiopathology
Ascites / etiology,  immunology,  physiopathology
Extravascular Lung Water / immunology
Lung / immunology,  physiopathology*
Lymph / immunology,  physiology*
Lymphatic System / immunology,  physiopathology*
Peritoneal Cavity
Pneumonia / etiology,  immunology,  physiopathology
Respiration, Artificial / adverse effects
Respiratory Distress Syndrome, Adult / etiology,  immunology,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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