| Lymphatics in human lymphatic filariasis: in vitro models of parasite-induced lymphatic remodeling. | |
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MedLine Citation:
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PMID: 20143920 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphatic filariasis characterized by the dysfunction of the lymphatics can lead to severe (and often) irreversible lymphedema and elephantiasis. Decades of research in the field shows that the establishment of the adult parasites in the lymphatics triggers a cascade of events that ultimately results in tissue scarring and fibrosis. In this minireview, we focus on the studies addressing the mechanisms underlying the parasite-induced lymphatic dilatation that suggests parasite-induced lymphatic remodeling and lymphangiogenesis may be the prelude towards developing chronic and irreversible filarial pathology. |
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Authors:
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Sasisekhar Bennuru; Thomas B Nutman |
Publication Detail:
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Type: In Vitro; Journal Article; Review |
Journal Detail:
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Title: Lymphatic research and biology Volume: 7 ISSN: 1557-8585 ISO Abbreviation: Lymphat Res Biol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-02-10 Completed Date: 2010-05-11 Revised Date: 2011-03-03 |
Medline Journal Info:
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Nlm Unique ID: 101163587 Medline TA: Lymphat Res Biol Country: United States |
Other Details:
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Languages: eng Pagination: 215-9 Citation Subset: IM |
Affiliation:
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Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0425, USA. bennurus@niaid.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal* Elephantiasis, Filarial / immunology, parasitology*, pathology Humans Lymphatic System / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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