Document Detail


Lymphatic vessels: pressure- and flow-dependent regulatory reactions.
MedLine Citation:
PMID:  18519963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This chapter discusses the current status of knowledge on basic pressure/stretch- and flow/shear-dependent regulatory reactions of contracting lymphangions in lymphatic vessels. The balance of passive and active lymph pumps is discussed; the data on pressure measurements in different lymphatic nets of several species are provided. The characteristics of typical changes in lymphatic contractility to the increases in transmural pressures are described and discussed, as is the role of pre-existing distension in initiation of lymphatic contractions. The up-to-date status of knowledge on flow-dependent adaptive reactions of contracting lymphangions is provided with detailed characterization of the influences of imposed and contraction-generated flows on lymphatic contractility. The interaction between extrinsic and intrinsic flows in regulation of lymphatic contractility is considered.
Authors:
Anatoliy A Gashev
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1131     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  100-9     Citation Subset:  IM    
Affiliation:
Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Division of Lymphatic Biology, College of Medicine, Texas A&M Health Science Center, 702 SW H.K. Dodgen Loop, Temple, TX 76504, USA. gashev@tamu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Homeostasis*
Humans
Lymphatic Vessels / physiology*
Pressure
Rheology

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