Document Detail

Lymphatic vessel density as a prognostic marker in clinical stage I endocervical adenocarcinoma.
MedLine Citation:
PMID:  20567154     Owner:  NLM     Status:  MEDLINE    
There are limited data evaluating the significance of lymphatic vessel density (LVD) as a prognostic marker in cervical adenocarcinoma. In this study, we investigated intratumoral and peritumoral LVD, using the lymphatic marker D2-40, as a prognostic marker in endocervical adenocarcinoma. Surgical specimens from 50 consecutive patients with endocervical adenocarcinoma treated with complete staging surgical procedures were reviewed. Selected tumor blocks were immunostained for D2-40 and CD31. Positively stained microvessels (MVs) were counted in densely vascular/lymphatic foci (hot spots) at 400x field in each specimen (0.17 mm). Results were expressed as the highest MV count identified within any single field. Both intratumoral CD31 MV and peritumoral D2-40 LVD showed significant correlation with depth of invasion (r=0.39, 0.37, respectively), percentage of circumferential involvement (r=0.36, 0.48, respectively), and lymphovascular invasion detected by D2-40 (r=0.45, 0.51, respectively; P<0.01). Only peritumoral D2-40 LVD showed a significant correlation with lymph node metastases (r=0.40; P<0.01), disease-free and overall survivals. Using univariate analysis, peritumoral D2-40 LVD showed significant correlation with lymphovascular invasion detected by D20-40 and lymph node metastases (P<0.05), which was maintained on multivariate analysis. D2-40 detected lymphovascular invasion in 16 of 50 (32%) cases, and showed a significant correlation with depth of invasion, lymph node metastases, involvement of parametrium (r=0.41, 0.38, 0.32, respectively; P<0.01), and disease-free survival. Our study showed that both angiogenesis and lymphangiogenesis play an important role in the progression of endocervical adenocarcinoma, and that peritumoral D2-40 LVD is an independent predictor of lymph node metastasis.
Reda S Saad; Nadia Ismiil; Zeina Ghorab; Sharon Nofech-Mozes; Valérie Dubé; Allan Covens; Mahmoud A Khalifa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  29     ISSN:  1538-7151     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  386-93     Citation Subset:  IM    
Department of Pathology, Sunnybrook Health Sciences Center/University of Toronto, Ontario Canada.
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MeSH Terms
Adenocarcinoma / blood supply,  pathology*
Antibodies, Monoclonal / diagnostic use
Antigens, CD31 / analysis,  metabolism
Disease-Free Survival
Kaplan-Meiers Estimate
Lymphangiogenesis / physiology*
Lymphatic Vessels / blood supply,  pathology*
Middle Aged
Tumor Markers, Biological / analysis
Uterine Cervical Neoplasms / blood supply,  pathology*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD31; 0/Tumor Markers, Biological; 0/monoclonal antibody D2-40

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