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Lymphatic vessel density as a predictor of lymph node metastasis and its relationship with prognosis in urothelial carcinoma of the bladder.
MedLine Citation:
PMID:  20883486     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: • To determine the correlation of lymphatic vessel density (LVD) with lymph node metastasis (LNM), investigate the impact of vascular endothelial growth factor (VEGF)-C mRNA expression on LVD, and evaluate the impact of LVD on prognosis of bladder urothelial carcinoma (BUC).
PATIENTS AND METHODS: • In 56 samples of BUC, the lymphatic vessels were immunostained with polyclonal antibodies against VEGF receptor 3 (VEGFR-3). LVD was evaluated in both intratumoural and peritumoural tissues. • The expression level of VEGF-C mRNA was assessed by reverse transcriptase-polymerase chain reaction. • The correlation of LVD with VEGF-C mRNA and other clinicopathological parameters was also investigated.
RESULTS: • VEGFR-3 was expressed in lymphatic vessel endothelial cytoplasm. As the expression level of VEGF-C became higher, the intratumoural and peritumoural LVD increased significantly (P < 0.05). • At the same time, increased intratumoural and peritumoural LVD also presented in patients with lymphatic vessel invasion and LNM of BUC (P < 0.05). • In addition, increased peritumoural LVD and LNM predicted a poor recurrence-free survival (P < 0.05).
CONCLUSIONS: • It is suggested that in BUC, VEGF-C expression may contribute to lymphangiogenesis. • Patients with high peritumoural LVD and LNM tend to have a poor prognosis. • Inhibition of the blocking VEGF-C/VEGFR-3 pathway may attenuate lymphangiogenesis and represent a new target for investigational treatment of urothelial carcinoma of the bladder.
Authors:
Mi Zhou; Leye He; Xiongbing Zu; Huihui Zhang; Huaide Zeng; Lin Qi
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Publication Detail:
Type:  Journal Article     Date:  2010-09-30
Journal Detail:
Title:  BJU international     Volume:  107     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1930-5     Citation Subset:  IM    
Copyright Information:
© 2010 THE AUTHORS. BJU INTERNATIONAL © 2010 BJU INTERNATIONAL.
Affiliation:
Department of Urology, Xiangya Hospital, Department of Urology, Third Xiangya Hospital, Central South University, Changsha city, Hunan Province, China.
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