| Lymphatic regulation of hematocrit during hypoxia in the toad Bufo woodhousei. | |
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MedLine Citation:
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PMID: 7485598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoxia rapidly increases hematocrit (Hct) in anuran amphibians by reducing plasma volume, but the mechanism(s) mediating this response is unknown. We tested the hypothesis that, during hypoxia, plasma volume is reduced by impaired lymph heart (LH) function, decreasing lymph flow into the circulation. In Bufo woodhousei, we measured the effects of hypoxia on Hct, lymph heart rate (LHR), LH pressure, the movement of dye from the dorsal lymph sac to the arterial blood, and flow through an open LH cannula. We also tested whether splenic contraction or cholinergic nerves contribute to the hypoxia-induced changes. Graded hypoxia between 21 and 4% O2 produced graded increases in Hct (P < 0.0001) and decreases in LHR (P = 0.01). Hypoxia reduced the rate of increase in arterial Evans blue concentration after injection into the dorsal lymph sac (P = 0.041) and decreased flow through an open LH cannula (P < 0.012). Hypoxia increased Hct and reduced LHR similarly in control, splenectomized, and sham-splenectomized toads. Atropine had no significant effect on Hct and LHR. These results indicate that the LHs play a regulatory role in hypoxia-induced hemoconcentration. |
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Authors:
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G M Malvin; S Macías; M Sanchez; R Dasalla; A Park; M Duran |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 269 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-12-12 Completed Date: 1995-12-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R814-21 Citation Subset: IM |
Affiliation:
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Cardiopulmonary Physiology Program, Institute for Basic and Applied Medical Research, Lovelace Institutes, Albuquerque, New Mexico 87108, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / physiopathology* Arteries Atropine / pharmacology Blood / metabolism Body Fluids / metabolism Hematocrit* Lymph / physiology Lymphatic System / physiopathology* Pressure Splenectomy |
| Grant Support | |
ID/Acronym/Agency:
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HL-07758/HL/NHLBI NIH HHS; HL-38942/HL/NHLBI NIH HHS; RR-03470/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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