| Lymphatic pump treatment increases thoracic duct lymph flow in conscious dogs with edema due to constriction of the inferior vena cava. | |
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MedLine Citation:
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PMID: 20863267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Osteopathic lymphatic pump treatments (LPT) are used to treat edema, but their direct effects on lymph flow have not been studied. In the current study, we examined the effects of LPT on lymph flow in the thoracic duct of instrumented conscious dogs in the presence of edema produced by constriction of the inferior vena cava (IVC). METHODS AND RESULTS: Six dogs were surgically instrumented with an ultrasonic flow transducer on the thoracic lymph duct and catheters in the descending thoracic aorta and in IVC. After postoperative recovery, lymph flow and hemodynamic variables were measured 1) pre-LPT, 2) during 4 min LPT, 3) post-LPT, in the absence and presence of edema produced by IVC constriction. This constriction increased abdominal girth from 60 +/-2.6 to 75 +/- 2.9 cm. Before IVC constriction, LPT increased lymph flow (P < 0.05) from 1.9 +/- 0.2 ml/min to a maximum of 4.7 +/-1.2 ml/min, whereas after IVC constriction, LPT increased lymph flow (P < 0.05) from 7.9 +/-2.2 to a maximum of 11.7 +/-2.2 ml/min. The incremental lymph flow mobilized by 4 min of LPT (ie, the flow that exceeded 4 min of baseline flow), was 10.6 ml after IVC constriction. This incremental flow was not significantly greater than that measured before IVC constriction. CONCLUSIONS: Edema caused by IVC constriction markedly increased lymph flow in the thoracic duct. LPT increased thoracic duct lymph flow before and after IVC constriction. The lymph flow mobilized by 4 min of LPT in presence of edema was not significantly greater than that mobilized prior to edema. |
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Authors:
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Parna Prajapati; Pankhil Shah; Hollis H King; Arthur G Williams; Pratikkumar Desai; H Fred Downey |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lymphatic research and biology Volume: 8 ISSN: 1557-8585 ISO Abbreviation: Lymphat Res Biol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2011-02-28 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 101163587 Medline TA: Lymphat Res Biol Country: United States |
Other Details:
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Languages: eng Pagination: 149-54 Citation Subset: IM |
Affiliation:
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Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen
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pathology Animals Aorta, Thoracic / physiopathology Catheterization Consciousness Constriction, Pathologic / complications Dogs Edema / etiology, physiopathology* Female Hemodynamics / physiology Lymph / physiology* Lymphatic System / physiopathology Male Manipulation, Osteopathic / methods Thoracic Duct / physiopathology* Vena Cava, Inferior / pathology, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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U19 AT002023/AT/NCCAM NIH HHS |
| Comments/Corrections | |
Comment In:
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Lymphat Res Biol. 2010 Sep;8(3):141
[PMID:
20863265
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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