| Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer. | |
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MedLine Citation:
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PMID: 16391866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The monoclonal antibody D2-40 is a new selective marker for lymphatic endothelium. The lymphatic microvessel density (LMVD) using D2-40 has not yet been evaluated in non-small cell lung cancer (NSCLC). The aim of this study was to evaluate LMVD using D2-40 in NSCLC. We investigated LMVD in 77 patients with NSCLC who underwent curative tumor resection. We also determined the relation between LMVD and clinicopathologic factors, VEGF-C and Ang-2 and microvessel density (MVD) using factor VIII-related antigen. The median number of D2-40-positive vessels in the highest LMVD was 25 (range, 5-71). LMVD was significantly associated with tumor status, lymph node metastasis, stage, lymphatic invasion, VEGF-C protein and MVD (p=0.0149 for tumor status; p<0.0001 for nodal status; p<0.0001 for stage; p=0.0153 for lymphatic invasion; p=0.0030 for VEGF-C, and p=0.0029 for MVD). Furthermore, LMVD using D2-40 expression was shown to be an independent predictor of lymph node metastasis by multivariate analysis (p=0.0070). These data indicate that a high LMVD by D2-40 may be an indicator of lymph node metastasis in NSCLC. |
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Authors:
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Iwao Takanami |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oncology reports Volume: 15 ISSN: 1021-335X ISO Abbreviation: Oncol. Rep. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-04 Completed Date: 2006-06-01 Revised Date: 2007-05-02 |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 437-42 Citation Subset: IM |
Affiliation:
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Department of Surgery, Teikyo University School of Medicine, 11-1 Kaga 2-Chome, Tokyo 173-8605, Japan. takanami@med.teikyo-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensins
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metabolism Antibodies, Monoclonal / diagnostic use* Carcinoma, Non-Small-Cell Lung / pathology* Endothelium, Lymphatic / metabolism* Female Humans Immunohistochemistry Lung Neoplasms / pathology* Lymphatic Metastasis / pathology* Male Neovascularization, Pathologic Prognosis Tumor Markers, Biological / analysis Vascular Endothelial Growth Factor C / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiotensins; 0/Antibodies, Monoclonal; 0/Tumor Markers, Biological; 0/VEGFC protein, human; 0/Vascular Endothelial Growth Factor C; 0/monoclonal antibody D2-40 |
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