Document Detail

Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer.
MedLine Citation:
PMID:  16391866     Owner:  NLM     Status:  MEDLINE    
The monoclonal antibody D2-40 is a new selective marker for lymphatic endothelium. The lymphatic microvessel density (LMVD) using D2-40 has not yet been evaluated in non-small cell lung cancer (NSCLC). The aim of this study was to evaluate LMVD using D2-40 in NSCLC. We investigated LMVD in 77 patients with NSCLC who underwent curative tumor resection. We also determined the relation between LMVD and clinicopathologic factors, VEGF-C and Ang-2 and microvessel density (MVD) using factor VIII-related antigen. The median number of D2-40-positive vessels in the highest LMVD was 25 (range, 5-71). LMVD was significantly associated with tumor status, lymph node metastasis, stage, lymphatic invasion, VEGF-C protein and MVD (p=0.0149 for tumor status; p<0.0001 for nodal status; p<0.0001 for stage; p=0.0153 for lymphatic invasion; p=0.0030 for VEGF-C, and p=0.0029 for MVD). Furthermore, LMVD using D2-40 expression was shown to be an independent predictor of lymph node metastasis by multivariate analysis (p=0.0070). These data indicate that a high LMVD by D2-40 may be an indicator of lymph node metastasis in NSCLC.
Iwao Takanami
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  15     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-04     Completed Date:  2006-06-01     Revised Date:  2007-05-02    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  IM    
Department of Surgery, Teikyo University School of Medicine, 11-1 Kaga 2-Chome, Tokyo 173-8605, Japan.
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MeSH Terms
Angiotensins / metabolism
Antibodies, Monoclonal / diagnostic use*
Carcinoma, Non-Small-Cell Lung / pathology*
Endothelium, Lymphatic / metabolism*
Lung Neoplasms / pathology*
Lymphatic Metastasis / pathology*
Neovascularization, Pathologic
Tumor Markers, Biological / analysis
Vascular Endothelial Growth Factor C / metabolism
Reg. No./Substance:
0/Angiotensins; 0/Antibodies, Monoclonal; 0/Tumor Markers, Biological; 0/VEGFC protein, human; 0/Vascular Endothelial Growth Factor C; 0/monoclonal antibody D2-40

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